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Introduction:

Drug-induced liver injury (DILI) is a significant concern in clinical practice as it can lead to liver failure and ultimately death. Understanding the biochemical basis of DILI is crucial for the development of effective prevention and treatment strategies. This thesis aims to investigate the underlying mechanisms of DILI at the molecular level, with a focus on how drugs interact with hepatic enzymes and cellular pathways to cause liver damage.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Epidemiology of DILI
2.2 Classification of DILI
2.3 Pathogenesis of DILI
2.4 Hepatotoxicity mechanisms
2.5 Genetic factors in DILI
2.6 Animal models of DILI
2.7 Biomarkers for DILI
2.8 Management of DILI
2.9 Current research trends in DILI
2.10 Gaps in current knowledge

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Laboratory techniques
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Quality control measures
3.8 Timeline for research

Chapter 4: Discussion of Findings
4.1 Drug-specific mechanisms of DILI
4.2 Role of cytochrome P450 enzymes in DILI
4.3 Oxidative stress and mitochondrial dysfunction in DILI
4.4 Inflammatory response in DILI
4.5 Apoptosis and necrosis in DILI
4.6 Role of immune cells in DILI
4.7 Novel therapeutic targets for DILI
4.8 Comparison with existing literature

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview:

Drug-induced liver injury (DILI) is a significant clinical problem that can result in serious adverse effects on the liver and overall health of the patient. The biochemical basis of DILI involves complex interactions between drugs, hepatic enzymes, and cellular pathways, leading to liver damage. This thesis aims to investigate the underlying mechanisms of DILI and provide insights into potential prevention and treatment strategies.

Chapter 1 provides an introduction to the topic, including background information, problem statement, objectives, limitations, scope, significance, and the structure of the thesis. Chapter 2 presents a comprehensive literature review on the epidemiology, classification, pathogenesis, mechanisms, genetic factors, biomarkers, management, and current research trends in DILI.

Chapter 3 describes the research methodology, including research design, study population, data collection methods, laboratory techniques, statistical analysis, ethical considerations, quality control measures, and timeline for the research. Chapter 4 discusses the findings of the study, focusing on drug-specific mechanisms of DILI, the role of cytochrome P450 enzymes, oxidative stress, mitochondrial dysfunction, inflammatory response, apoptosis, necrosis, immune cells, and potential therapeutic targets.

Chapter 5 concludes the thesis with a summary of key findings, implications for clinical practice, recommendations for future research, and a final conclusion. Overall, this thesis aims to contribute to the understanding of the biochemical basis of DILI and provide valuable insights for improving the management and outcomes of patients with DILI.

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