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Introduction

Bioavailability refers to the proportion of a drug or other substance that enters the bloodstream when introduced into the body and is able to have an active effect. Enhancing the bioavailability of molecules with poor membrane permeability is a critical aspect of drug development and delivery. Poor membrane permeability can limit the effectiveness of a drug, as it may not be able to reach its target site in sufficient quantities to produce the desired therapeutic effect. Therefore, various strategies must be employed to improve the bioavailability of such molecules.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of bioavailability enhancement strategies
2.2 Importance of bioavailability in drug delivery
2.3 Factors affecting membrane permeability
2.4 Current challenges in enhancing bioavailability
2.5 Lipid-based drug delivery systems
2.6 Nanoparticle-based drug delivery systems
2.7 Prodrug approaches
2.8 Formulation approaches
2.9 Combination therapy for bioavailability enhancement
2.10 Future directions in bioavailability enhancement

Chapter 3: Research Methodology
3.1 Research design
3.2 Data collection methods
3.3 Sample selection
3.4 Data analysis
3.5 Ethical considerations
3.6 Research limitations
3.7 Validation of methodology
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Analysis of bioavailability enhancement strategies
4.2 Comparison of different approaches
4.3 Identification of key factors for success
4.4 Implications for drug development
4.5 Future research directions
4.6 Limitations of the study
4.7 Recommendations for practice
4.8 Theoretical implications

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Conclusions drawn from the study
5.3 Implications for the field
5.4 Recommendations for further research
5.5 Final thoughts

Thesis Overview
Bioavailability enhancement strategies for molecules with poor membrane permeability is a critical area of research in the field of drug delivery. This thesis aims to provide a comprehensive overview of the current strategies used to improve the bioavailability of poorly permeable molecules. Chapter 1 will introduce the topic, provide background information, outline the problem statement, objectives, limitations, scope, significance, and structure of the thesis. Chapter 2 will review relevant literature on bioavailability enhancement strategies, including lipid-based drug delivery systems, nanoparticle-based drug delivery systems, prodrug approaches, formulation approaches, and combination therapy. Chapter 3 will detail the research methodology, including research design, data collection methods, sample selection, data analysis, ethical considerations, limitations, and validation of methodology. Chapter 4 will discuss the findings of the study, analyze different bioavailability enhancement strategies, compare approaches, identify key success factors, and suggest future research directions. Finally, Chapter 5 will present the conclusions and summarize the key findings of the thesis, providing implications for the field, recommendations for further research, and final thoughts on the topic.

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