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Introduction

Huntingtonʼs disease is a progressive neurodegenerative disorder with no cure, characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. Recent advancements in gene editing technology, specifically CRISPR-based gene therapy, have shown promise in potentially treating genetic disorders such as Huntingtonʼs disease. This thesis aims to assess the potential of CRISPR-based gene therapy for the treatment of Huntingtonʼs disease, including the underlying mechanisms, current research findings, and future implications.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Huntingtonʼs disease
2.2 Genetic basis of Huntingtonʼs disease
2.3 CRISPR-based gene editing technology
2.4 Previous studies on CRISPR-based gene therapy for Huntingtonʼs disease
2.5 Challenges and limitations of CRISPR-based gene therapy
2.6 Ethical considerations in gene editing research
2.7 Future directions in gene therapy for Huntingtonʼs disease
2.8 Comparison with other gene therapy approaches
2.9 Regulatory landscape for gene editing in healthcare
2.10 Potential impact of CRISPR technology on the field of medicine

Chapter 3: Research Methodology
3.1 Research design
3.2 Sampling strategy
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Recruitment process
3.7 Data validation methods
3.8 Research limitations

Chapter 4: Discussion of Findings
4.1 Overview of research findings
4.2 Effectiveness of CRISPR-based gene therapy for Huntingtonʼs disease
4.3 Safety concerns and ethical implications
4.4 Comparison with traditional treatment options
4.5 Future prospects for gene therapy research
4.6 Patient perspectives and quality of life outcomes
4.7 Challenges and barriers to implementing gene therapy
4.8 Recommendations for future research and clinical practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for policy and practice
5.4 Limitations of the study
5.5 Future research directions

Thesis Overview:

Huntingtonʼs disease is a devastating neurodegenerative disorder with a genetic basis that has driven researchers to explore novel treatment approaches, including gene therapy. This thesis will delve into the potential of CRISPR-based gene therapy for the treatment of Huntingtonʼs disease, examining the underlying mechanisms and current research findings. Through a comprehensive literature review and detailed research methodology, this thesis aims to provide insights into the efficacy and safety of CRISPR technology in treating Huntingtonʼs disease. The discussion of findings will analyze the implications of gene therapy for patients, as well as highlight the challenges and future prospects in this exciting field of research. In conclusion, this thesis will offer recommendations for future research and clinical practice, aiming to contribute to the advancement of gene therapy for Huntingtonʼs disease.

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