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Introduction

Drug-induced neurotoxicity is a serious concern in drug development, as it can lead to various neurological disorders and even death in extreme cases. The ability to accurately assess neurotoxicity is crucial for the safety and efficacy of new drugs before they reach the market. Traditional methods of assessing neurotoxicity often rely on animal models and behavioral assessments, which are time-consuming, expensive, and may not accurately reflect human neurotoxicity. In recent years, there has been a growing interest in the use of novel biomarkers as a more efficient and reliable method for assessing drug-induced neurotoxicity.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of drug-induced neurotoxicity
2.2 Current methods of neurotoxicity assessment
2.3 Novel biomarkers in neurotoxicity assessment
2.4 Role of neuroinflammation in neurotoxicity
2.5 Genetic factors influencing neurotoxicity
2.6 Pharmacogenomics and neurotoxicity
2.7 Neuroimaging techniques in neurotoxicity assessment
2.8 Preclinical models of neurotoxicity
2.9 Challenges in neurotoxicity assessment
2.10 Future directions in neurotoxicity research

Chapter 3: Research Methodology
3.1 Research design
3.2 Selection of study participants
3.3 Data collection methods
3.4 Measurement of biomarkers
3.5 Data analysis techniques
3.6 Ethical considerations
3.7 Validation of novel biomarkers
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Comparison of traditional and novel biomarker methods
4.3 Implications for drug development
4.4 Potential applications of novel biomarkers
4.5 Limitations of the study
4.6 Recommendations for future research

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Conclusions
5.3 Implications for drug development
5.4 Recommendations for future research

Thesis Overview

The impact of drug-induced neurotoxicity on drug development is a significant issue that requires thorough analysis and evaluation. This thesis aims to investigate the potential role of novel biomarkers in the assessment of drug-induced neurotoxicity. By reviewing the current literature on neurotoxicity assessment methods, exploring the challenges and limitations in the field, and proposing novel approaches using biomarkers, this research seeks to provide valuable insights for drug developers, regulatory agencies, and healthcare professionals. The findings of this study are expected to contribute to the advancement of drug safety and efficacy evaluations, ultimately improving patient outcomes and public health.

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