Design and development of a microfluidic device for biomedical applications – Complete Phd and Masters Thesis

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Introduction

The field of microfluidics has gained significant attention in recent years due to its potential applications in various fields such as biomedical, chemical, and environmental engineering. Microfluidic devices offer unique advantages over traditional macroscale devices including lower reagent consumption, faster reaction rates, and increased sensitivity. In the biomedical field, microfluidic devices have been utilized for a wide range of applications including drug delivery, cell manipulation, and point-of-care diagnostics.

This thesis focuses on the design and development of a microfluidic device specifically for biomedical applications. The device will be capable of performing various functions such as cell sorting, drug screening, and biomarker detection. The goal of this research is to explore the potential of microfluidic devices in advancing biomedical research and clinical diagnostics.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of microfluidics
2.2 Microfluidic technologies in biomedical applications
2.3 Cell sorting techniques
2.4 Drug screening methods
2.5 Biomarker detection
2.6 Recent advancements in microfluidic devices
2.7 Challenges in microfluidic device design
2.8 Commercial microfluidic platforms
2.9 Integration of microfluidics with other technologies
2.10 Future trends in microfluidics research

Chapter 3: System Design and Methodology
3.1 Design requirements
3.2 Conceptual design
3.3 Selection of materials
3.4 Fabrication techniques
3.5 Fluidic control systems
3.6 Integration of sensors
3.7 Testing and validation
3.8 Optimization of device performance

Chapter 4: System Implementation
4.1 Device assembly
4.2 Testing protocols
4.3 Characterization of device performance
4.4 Data analysis techniques
4.5 Performance evaluation
4.6 Comparison with existing technologies
4.7 Scalability and production considerations
4.8 Future improvements and modifications

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview

The design and development of a microfluidic device for biomedical applications is a critical area of research that has the potential to revolutionize the field of biomedical engineering. This thesis aims to investigate the feasibility and effectiveness of utilizing microfluidic devices for various biomedical applications including cell sorting, drug screening, and biomarker detection.

Chapter 1 provides an introduction to the research topic, outlining the background, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. Chapter 2 presents a comprehensive literature review on microfluidics, focusing on its applications in biomedicine, recent advancements, challenges, commercial platforms, and future trends.

Chapter 3 details the system design and methodology, covering design requirements, conceptual design, material selection, fabrication techniques, fluidic control systems, sensor integration, testing, validation, and performance optimization. Chapter 4 describes the system implementation phase, including device assembly, testing protocols, characterization, data analysis, performance evaluation, comparison with existing technologies, scalability considerations, and future improvements.

Chapter 5 concludes the thesis with a summary of key findings, contributions to the field, recommendations for future research, and a final conclusion on the design and development of the microfluidic device for biomedical applications. This thesis aims to provide valuable insights into the potential of microfluidic devices in advancing biomedical research and clinical diagnostics, ultimately contributing to the advancement of biomedical engineering as a whole.

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