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Introduction:

Depression is a prevalent mental health disorder that affects millions of people worldwide. Despite advancements in understanding the neurobiology of depression, the specific mechanisms underlying neural circuit dysfunction in depression remain unclear. This thesis aims to investigate the mechanisms of neural circuit dysfunction in depression, shedding light on potential targets for therapeutic interventions.

Chapter One: Mechanisms of neural circuit dysfunction in depression
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
2.1 Overview of depression
2.2 Neurobiological theories of depression
2.3 Neural circuits implicated in depression
2.4 Neurotransmitter systems in depression
2.5 Neuroplasticity and depression
2.6 Role of inflammation in depression
2.7 Stress and depression
2.8 Genetic factors in depression
2.9 Animal models of depression
2.10 Current treatment approaches for depression

Chapter Three: Research Methodology
3.1 Research design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Measurement tools
3.7 Statistical analysis
3.8 Study limitations

Chapter Four: Discussion of Findings
4.1 Overview of findings
4.2 Neural circuit abnormalities in depression
4.3 Implications for treatment
4.4 Future directions for research
4.5 Comparison with existing literature
4.6 Strengths and limitations of the study

Chapter Five: Conclusion and Summary
5.1 Recap of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview:

Depression is a complex mental health disorder with neural circuit dysfunction at its core. This thesis explores the mechanisms underlying neural circuit dysfunction in depression, drawing on current literature and original research. Chapters one and two provide an introduction and comprehensive literature review, setting the stage for the research methodology outlined in chapter three. The discussion of findings in chapter four offers insights into the neural circuit abnormalities in depression and potential therapeutic targets. Finally, chapter five concludes the thesis with a summary of key findings and recommendations for future research in this important area of study.

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