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Introduction:

Alzheimer’s disease is a progressive neurodegenerative disorder that primarily affects the elderly population, causing cognitive decline, memory loss, and ultimately, complete loss of independence. While much research has been conducted on the underlying pathology of Alzheimer’s disease, the exact mechanisms leading to neuronal dysfunction and degeneration remain unclear. Recent studies have suggested that neurovascular dysfunction may play a crucial role in the development and progression of Alzheimer’s disease. The dysfunction of the blood-brain barrier, impaired cerebral blood flow regulation, and altered neurovascular coupling have all been implicated in the pathogenesis of Alzheimer’s disease.

This thesis aims to investigate the role of neurovascular dysfunction in Alzheimer’s disease and its potential implications for disease progression. By unraveling the intricate relationship between neurovascular dysfunction and Alzheimer’s disease, this study has the potential to identify novel therapeutic targets and diagnostic markers for this devastating condition.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Neurovascular dysfunction in Alzheimer’s disease
2.2 Pathophysiology of Alzheimer’s disease
2.3 Blood-brain barrier dysfunction in Alzheimer’s disease
2.4 Cerebral blood flow regulation in Alzheimer’s disease
2.5 Neurovascular coupling in Alzheimer’s disease
2.6 Imaging techniques for assessing neurovascular dysfunction in Alzheimer’s disease
2.7 Therapeutic targets for neurovascular dysfunction in Alzheimer’s disease
2.8 Diagnostic markers for neurovascular dysfunction in Alzheimer’s disease
2.9 Animal models of neurovascular dysfunction in Alzheimer’s disease
2.10 Future directions in research on neurovascular dysfunction in Alzheimer’s disease

Chapter 3: Research Methodology
3.1 Study design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Statistical analysis
3.7 Power analysis
3.8 Quality assurance

Chapter 4: Discussion of Findings
4.1 Neurovascular dysfunction in Alzheimer’s disease
4.2 Implications for disease progression
4.3 Novel therapeutic targets
4.4 Diagnostic markers
4.5 Animal models
4.6 Clinical relevance
4.7 Limitations of the study
4.8 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Overall, this thesis will provide a comprehensive overview of the current understanding of neurovascular dysfunction in Alzheimer’s disease and offer new insights into potential therapeutic strategies and diagnostic approaches for this devastating condition.

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