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Introduction

Neurovascular coupling is the intricate relationship between neuronal activity and blood flow regulation in the brain. This phenomenon plays a crucial role in maintaining the balance between oxygen supply and demand in the brain, ultimately affecting various cognitive functions. Dysfunction in neurovascular coupling has been implicated in the pathophysiology of several neurological disorders, such as stroke, Alzheimer’s disease, and epilepsy. Understanding the mechanisms underlying neurovascular coupling in health and disease is essential for the development of targeted therapeutic interventions.

This thesis aims to investigate neurovascular coupling in disease, focusing on identifying the molecular and cellular mechanisms involved, as well as exploring potential therapeutic targets. By employing a multidisciplinary approach, combining neuroimaging techniques, electrophysiology, and molecular biology, this study aims to shed light on the complex interplay between neural activity and vascular responses in disease states.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of neurovascular coupling
2.2 Neurovascular coupling in health
2.3 Neurovascular coupling in disease
2.4 Molecular mechanisms of neurovascular coupling
2.5 Cellular mechanisms of neurovascular coupling
2.6 Neuroimaging techniques for studying neurovascular coupling
2.7 Therapeutic targets for neurovascular coupling
2.8 Current challenges in studying neurovascular coupling
2.9 Future directions in neurovascular coupling research

Chapter 3: Research Methodology
3.1 Study design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Validation of findings
3.8 Potential limitations

Chapter 4: Discussion of Findings
4.1 Neurovascular coupling in disease models
4.2 Molecular pathways involved in dysfunctional neurovascular coupling
4.3 Cellular mechanisms underlying neurovascular dysfunction
4.4 Implications for therapeutic interventions
4.5 Comparison with existing literature
4.6 Strengths and limitations of the study
4.7 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Contributions to the field
5.4 Limitations of the study
5.5 Recommendations for future research
5.6 Conclusion

Thesis Overview

Investigation of neurovascular coupling in disease is a critical area of research that has significant implications for understanding the pathophysiology of neurological disorders. This thesis aims to explore the complex interplay between neuronal activity and blood flow regulation in disease states, with a focus on identifying potential therapeutic targets. By conducting a comprehensive literature review, utilizing advanced research methodologies, and engaging in in-depth discussions of findings, this study aims to contribute to the growing body of knowledge on neurovascular coupling.

The introduction chapter provides a background of the study, outlines the problem statement, objectives, limitations, scope, significance, and structure of the thesis. The literature review chapter synthesizes existing knowledge on neurovascular coupling, highlighting key concepts, mechanisms, and current research gaps. The research methodology chapter details the study design, participant selection, data collection and analysis methods, ethical considerations, and potential limitations.

The discussion of findings chapter presents the results of the study, including insights into neurovascular coupling in disease models, molecular and cellular mechanisms, therapeutic targets, and implications for future research. The conclusion and summary chapter summarizes the key findings, highlights the clinical implications, discusses the contributions to the field, and provides recommendations for future research directions.

Overall, this thesis aims to advance our understanding of neurovascular coupling in disease and ultimately contribute to the development of novel therapeutic strategies for neurological disorders.

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