Introduction
Cancer is a complex and multifaceted disease that arises from genetic mutations and dysregulation of various cellular processes. One key aspect of cancer progression is the alteration of cellular metabolism, which allows cancer cells to sustain their rapid growth and proliferation. MicroRNAs, small non-coding RNAs that regulate gene expression, have emerged as important players in cancer metabolism by modulating key metabolic pathways. This thesis aims to explore the role of microRNAs in cancer metabolism and their potential as therapeutic targets in cancer treatment.
Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms
Chapter 2: Literature Review
2.1 Overview of cancer metabolism
2.2 Role of microRNAs in cancer development
2.3 MicroRNAs and metabolic reprogramming in cancer
2.4 Regulation of key metabolic pathways by microRNAs
2.5 Clinical relevance of microRNAs in cancer metabolism
2.6 Therapeutic targeting of microRNAs in cancer treatment
2.7 Challenges and future directions in microRNA research
2.8 Role of microRNAs in specific cancer types
2.9 Interplay between microRNAs and oncogenes/tumor suppressors
2.10 MicroRNA biomarkers in cancer metabolism
Chapter 3: Research Methodology
3.1 Study design
3.2 Sample collection and processing
3.3 MicroRNA profiling techniques
3.4 Metabolic assays
3.5 Cell culture and animal models
3.6 Data analysis
3.7 Statistical methods
3.8 Ethical considerations
Chapter 4: Discussion of Findings
4.1 MicroRNAs dysregulation in cancer metabolism
4.2 Impact of microRNAs on key metabolic pathways
4.3 Therapeutic potential of targeting microRNAs in cancer treatment
4.4 Clinical implications of microRNA-based therapies
4.5 Comparison with existing cancer treatments
4.6 Future research directions
4.7 Limitations of the study
4.8 Implications for cancer management
Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for cancer research and treatment
5.3 Recommendations for future studies
5.4 Conclusion
Thesis Overview on Role of microRNAs in cancer metabolism
Cancer is a devastating disease characterized by uncontrolled cell growth and proliferation. One of the hallmarks of cancer is the rewiring of cellular metabolism to meet the high energy demands of rapidly dividing cancer cells. MicroRNAs, small non-coding RNAs that regulate gene expression, have been implicated in the dysregulation of metabolic pathways in cancer. This thesis aims to investigate the role of microRNAs in cancer metabolism and their potential as therapeutic targets in cancer treatment.
Chapter 1 provides an introduction to the topic, including background information, the problem statement, objectives of the study, limitations, scope, significance, and structure of the thesis. Chapter 2 presents a comprehensive review of the literature on cancer metabolism, the role of microRNAs in cancer development, and their impact on key metabolic pathways. Chapter 3 outlines the research methodology, including study design, sample collection, microRNA profiling techniques, metabolic assays, data analysis, and ethical considerations.
In Chapter 4, the findings of the study are discussed, including the dysregulation of microRNAs in cancer metabolism, the impact on metabolic pathways, therapeutic potential, clinical implications, and future research directions. Finally, Chapter 5 provides a summary of the key findings, implications for cancer research and treatment, recommendations for future studies, and a conclusion on the role of microRNAs in cancer metabolism.
