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Introduction

Anorexia nervosa is a complex psychiatric disorder characterized by restricted food intake, intense fear of gaining weight, and distorted body image. Despite advances in understanding the etiology and treatment of anorexia nervosa, the underlying biological mechanisms remain poorly understood. Metabolomics, the comprehensive study of small molecule metabolites in biological systems, has emerged as a powerful tool for investigating the metabolic changes associated with various diseases, including anorexia nervosa. By profiling the metabolites present in biological samples, metabolomics can provide valuable insights into the molecular pathways dysregulated in anorexia nervosa and potential biomarkers for diagnosis and monitoring of the disease.

Chapter One: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter Two: Literature Review
2.1 Overview of Anorexia Nervosa
2.2 Current Understanding of Metabolic Dysregulation in Anorexia Nervosa
2.3 Metabolomics Techniques and Applications
2.4 Metabolomics Studies in Eating Disorders
2.5 Potential Metabolite Biomarkers in Anorexia Nervosa
2.6 Integration of Metabolomics with Other Omics Technologies
2.7 Challenges and Future Directions in Metabolomics Research of Anorexia Nervosa

Chapter Three: Research Methodology
3.1 Study Design and Population
3.2 Sample Collection and Preparation
3.3 Metabolomics Profiling Techniques
3.4 Data Analysis and Interpretation
3.5 Statistical Analysis
3.6 Validation of Metabolite Biomarkers
3.7 Ethical Considerations
3.8 Timeline and Budget

Chapter Four: Discussion of Findings
4.1 Overview of Metabolomics Profiling in Anorexia Nervosa
4.2 Identification of Dysregulated Metabolic Pathways
4.3 Validation of Metabolite Biomarkers
4.4 Comparison with Previous Studies
4.5 Implications for Diagnosis and Treatment
4.6 Future Research Directions
4.7 Limitations of the Study

Chapter Five: Conclusion
5.1 Summary of Findings
5.2 Conclusions
5.3 Recommendations for Future Research
5.4 Practical Implications
5.5 Contribution to the Field of Metabolomics and Anorexia Nervosa

Thesis Overview on Metabolomics of Anorexia Nervosa

Anorexia nervosa is a serious mental health disorder characterized by severe weight loss, distorted body image, and an intense fear of gaining weight. Despite the growing understanding of the psychological and social factors contributing to anorexia nervosa, the biological mechanisms underlying the disease remain poorly understood. Metabolomics, a comprehensive study of the small molecule metabolites in biological systems, offers a unique opportunity to investigate the metabolic changes associated with anorexia nervosa and identify potential biomarkers for diagnosis and treatment.

This thesis aims to explore the application of metabolomics in the study of anorexia nervosa, with a focus on identifying metabolic signatures associated with the disease and potential biomarkers for early detection and monitoring of recovery. The research will involve profiling the metabolites present in blood samples from individuals with anorexia nervosa and healthy controls, using state-of-the-art metabolomics techniques. By comparing the metabolic profiles between the two groups, we hope to uncover the key metabolic pathways dysregulated in anorexia nervosa and identify potential biomarkers for further validation.

The thesis will be structured into five chapters, beginning with an introduction to anorexia nervosa and the rationale for studying metabolomics in the context of the disease. The literature review will provide a comprehensive overview of the current understanding of anorexia nervosa, metabolic dysregulation in eating disorders, and the applications of metabolomics in disease research. The methodology chapter will outline the study design, sample collection, metabolomics techniques, data analysis, and ethical considerations.

The discussion of findings chapter will present the results of the metabolomics profiling in anorexia nervosa, including the identification of dysregulated metabolic pathways and potential biomarkers. The conclusion chapter will summarize the key findings, discuss their implications for diagnosis and treatment of anorexia nervosa, and outline recommendations for future research in the field of metabolomics and eating disorders. Overall, this thesis aims to contribute to the growing body of knowledge on the biological mechanisms of anorexia nervosa and pave the way for new diagnostic and therapeutic strategies based on metabolomics.

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