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Introduction

Huntington’s disease (HD) is a devastating neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms. Despite significant advances in understanding the genetic basis of HD, there is still a need for a deeper understanding of the metabolic alterations that occur in the context of this disease. Metabolomics, the study of small molecules involved in cellular processes, provides a comprehensive snapshot of the metabolic state of an individual and has the potential to uncover novel biomarkers and therapeutic targets for HD. This thesis aims to investigate the metabolomic profile of individuals with HD to gain insight into the underlying metabolic disturbances and to identify potential metabolic targets for therapeutic intervention.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Huntington’s disease
2.2 Current treatment options for Huntington’s disease
2.3 Metabolomic studies in neurodegenerative diseases
2.4 Metabolomic profiling in Huntington’s disease
2.5 Potential metabolic pathways implicated in Huntington’s disease
2.6 Biomarkers for Huntington’s disease
2.7 Therapeutic targets in Huntington’s disease
2.8 Challenges in metabolomic studies of neurodegenerative diseases
2.9 Advances in metabolomic technology
2.10 Future perspectives in metabolomics research of Huntington’s disease

Chapter 3: Research Methodology
3.1 Study design
3.2 Participant recruitment
3.3 Sample collection and preparation
3.4 Metabolomic analysis techniques
3.5 Data analysis
3.6 Statistical methods
3.7 Validation of findings
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Metabolic alterations in individuals with Huntington’s disease
4.2 Identification of potential biomarkers for Huntington’s disease
4.3 Implications for disease progression and pathogenesis
4.4 Comparison with previous metabolomic studies
4.5 Therapeutic implications of findings
4.6 Future directions in metabolomics research of Huntington’s disease

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Limitations of the study
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview

Huntington’s disease (HD) is a devastating neurodegenerative disorder for which there is currently no cure. The genetic basis of HD has been extensively studied, but the metabolic alterations that contribute to disease progression remain poorly understood. Metabolomics, the study of small molecules involved in cellular processes, offers a unique opportunity to investigate the metabolic changes that occur in the context of HD. This thesis aims to explore the metabolomic profile of individuals with HD and to identify potential biomarkers and therapeutic targets for the disease.

The literature review section provides an overview of HD, current treatment options, and the role of metabolomics in neurodegenerative diseases. It also discusses potential metabolic pathways implicated in HD, biomarkers for the disease, and challenges in metabolomic studies of neurodegenerative disorders. The chapter concludes with a discussion of future perspectives in metabolomics research of HD.

The research methodology section outlines the study design, participant recruitment, sample collection and preparation, metabolomic analysis techniques, data analysis, statistical methods, and ethical considerations. The chapter provides a detailed description of the methods used to investigate the metabolomic profile of individuals with HD.

The discussion of findings section presents the results of the metabolomic analysis, including metabolic alterations in individuals with HD, potential biomarkers for the disease, and implications for disease progression and pathogenesis. The chapter also explores the therapeutic implications of the findings and discusses future directions in metabolomics research of HD.

In conclusion, this thesis provides a comprehensive investigation of the metabolomic profile of individuals with Huntington’s disease. The findings of this study could have significant implications for the development of novel biomarkers and therapeutic targets for HD. Additionally, the research methodology and data analysis techniques outlined in this thesis may serve as a valuable resource for future metabolomics research in neurodegenerative diseases.

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