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Introduction

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central nervous system. These diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS), currently have no cure and present a significant burden on patients, caregivers, and healthcare systems worldwide. Drug repurposing, also known as drug repositioning or drug reprofiling, is the process of discovering new therapeutic uses for existing drugs that are already approved for other indications. This approach holds great promise for the treatment of neurodegenerative diseases, as it allows for the rapid identification of potential treatments with known safety profiles.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of neurodegenerative diseases
2.2 Current treatment options
2.3 Drug repurposing in neurology
2.4 Mechanisms of action in drug repurposing
2.5 Success stories in drug repurposing for neurodegenerative diseases
2.6 Challenges in drug repurposing
2.7 Computational approaches in drug repurposing
2.8 Preclinical and clinical studies in drug repurposing
2.9 Regulatory considerations
2.10 Future perspectives in drug repurposing for neurodegenerative diseases

Chapter 3: Research Methodology
3.1 Research design
3.2 Data collection methods
3.3 Data analysis techniques
3.4 Sample selection
3.5 Study population
3.6 Ethical considerations
3.7 Variables and measures
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Comparison with existing literature
4.3 Implications for clinical practice
4.4 Limitations of the study
4.5 Recommendations for future research

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Practical implications
5.4 Suggestions for further research

Thesis Overview on Drug Repurposing for Neurodegenerative Diseases

Neurodegenerative diseases pose a significant challenge in healthcare due to their debilitating nature and lack of effective treatment options. Drug repurposing, the process of identifying new uses for existing drugs, offers a promising approach to finding novel therapies for these conditions. This thesis explores the potential of drug repurposing in the treatment of neurodegenerative diseases, focusing on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and ALS.

The introduction provides an overview of neurodegenerative diseases, the challenges they present, and the potential benefits of drug repurposing in addressing these challenges. The literature review examines current treatment options, the principles of drug repurposing, success stories in the field, challenges, computational approaches, and regulatory considerations. The research methodology outlines the design of the study, data collection methods, analysis techniques, and ethical considerations.

The discussion of findings presents the results of the study, comparing them with existing literature, discussing implications for clinical practice, and identifying limitations and recommendations for future research. The conclusion summarizes key findings, contributions to the field, practical implications, and suggestions for further research.

Overall, this thesis aims to contribute to the growing body of research on drug repurposing for neurodegenerative diseases, providing insights into the potential of this approach to address the unmet medical needs of patients with these conditions.

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