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Introduction
Cellular senescence is a phenomenon characterized by a permanent growth arrest of cells that occurs in response to various factors such as DNA damage, telomere shortening, oxidative stress, and oncogene activation. This process plays a crucial role in aging and age-related diseases, as well as in tumor suppression. Understanding the biochemical mechanisms underlying cellular senescence is essential for developing strategies to delay aging and treat age-related diseases.
Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms
Chapter 2: Literature Review
2.1 Overview of cellular senescence
2.2 Biochemical pathways involved in cellular senescence
2.3 Telomere shortening and cellular senescence
2.4 DNA damage response and cellular senescence
2.5 Oxidative stress and cellular senescence
2.6 Senescence-associated secretory phenotype (SASP)
2.7 Epigenetic regulation of cellular senescence
2.8 Senescence in age-related diseases
2.9 Senescence in cancer
2.10 Therapeutic targeting of cellular senescence
Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Validation of results
3.7 Statistical analysis
3.8 Quality control measures
Chapter 4: Discussion of Findings
4.1 Molecular mechanisms of cellular senescence
4.2 Crosstalk between different pathways in cellular senescence
4.3 Implications of cellular senescence in aging
4.4 Therapeutic strategies targeting cellular senescence
4.5 Challenges and future directions in the field of cellular senescence research
Chapter 5: Conclusion and Summary
In conclusion, the study of biochemical mechanisms of cellular senescence is crucial for understanding the aging process and developing interventions to delay aging and treat age-related diseases. By unraveling the intricate signaling pathways involved in cellular senescence, researchers can identify novel targets for therapeutic interventions. This thesis aims to contribute to the growing body of knowledge in this field and pave the way for future research in the biology of aging.
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