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Introduction:

Alzheimer’s disease is a devastating neurodegenerative disorder that primarily affects memory and other cognitive functions. One particular aspect of memory that is often impaired in individuals with Alzheimer’s disease is source memory, which involves remembering the context in which information was acquired. Neuroimaging techniques have provided valuable insights into the neural mechanisms underlying source memory impairment in Alzheimer’s disease.

This thesis aims to explore the neuroimaging of source memory in Alzheimer’s disease, with a focus on understanding how structural and functional brain changes contribute to source memory deficits in individuals with Alzheimer’s disease. By utilizing advanced neuroimaging methods, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), this study will investigate the neural substrates of source memory impairment in Alzheimer’s disease.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Alzheimer’s disease
2.2 Memory impairment in Alzheimer’s disease
2.3 Source memory and its neural mechanisms
2.4 Neuroimaging techniques in Alzheimer’s disease research
2.5 Neuroimaging studies on source memory in Alzheimer’s disease
2.6 Structural neuroimaging findings
2.7 Functional neuroimaging findings
2.8 Neuroimaging biomarkers of source memory impairment
2.9 The role of amyloid and tau pathology in source memory deficits
2.10 Future directions in neuroimaging research on source memory in Alzheimer’s disease

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Neuroimaging data acquisition
3.4 Data preprocessing and analysis
3.5 Source memory task paradigm
3.6 Behavioral assessments
3.7 Neuroimaging data analysis
3.8 Statistical analysis
3.9 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Structural brain changes in relation to source memory deficits
4.2 Functional brain alterations associated with source memory impairment
4.3 Neuroimaging biomarkers of source memory impairment
4.4 Relationship between amyloid and tau pathology and source memory deficits
4.5 Implications of neuroimaging findings for early detection and intervention
4.6 Limitations of the study
4.7 Future research directions
4.8 Clinical implications

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to the field
5.3 Practical implications
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview:

Neuroimaging techniques have revolutionized our understanding of Alzheimer’s disease, particularly in the realm of memory deficits such as source memory impairment. This thesis aims to investigate the neural underpinnings of source memory deficits in individuals with Alzheimer’s disease using advanced neuroimaging methods. By examining structural and functional brain changes associated with source memory impairment, this study will contribute to the growing body of knowledge on the neurobiology of Alzheimer’s disease.

The literature review will provide a comprehensive overview of Alzheimer’s disease, memory impairment, source memory, and neuroimaging techniques in Alzheimer’s disease research. The research methodology section will detail the study design, participant recruitment, neuroimaging data acquisition, source memory task paradigm, data analysis procedures, and ethical considerations.

The discussion of findings will present the results of the neuroimaging analysis, including structural and functional brain alterations related to source memory deficits, neuroimaging biomarkers, and the role of amyloid and tau pathology. The conclusion and summary will highlight the key findings of the study, their implications for clinical practice, recommendations for future research, and the overall contribution of this thesis to the field of neuroimaging in Alzheimer’s disease research.

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