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Introduction

Major depressive disorder is a prevalent and debilitating mental illness that affects millions of people worldwide. Despite the availability of various treatments, a significant proportion of individuals with depression do not respond adequately to standard therapies, such as antidepressant medications and psychotherapy. This subset of patients is classified as having treatment-resistant depression (TRD), which poses a significant challenge to clinicians and researchers.

Transcranial magnetic stimulation (TMS) is a promising alternative treatment for TRD that has gained increasing attention in recent years. TMS works by applying magnetic pulses to specific areas of the brain, modulating neural activity and potentially alleviating depressive symptoms. While TMS has shown promising results in some studies, its effectiveness and mechanisms of action in TRD are not yet fully understood.

This thesis aims to investigate the effects of TMS on TRD, exploring its potential as a novel treatment option for individuals who do not respond to conventional therapies. By examining the existing literature, conducting empirical research, and analyzing the findings, this study seeks to contribute to our understanding of the role of TMS in the management of TRD.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Major Depressive Disorder
2.2 Treatment-Resistant Depression
2.3 Current Treatment Options for TRD
2.4 Basics of Transcranial Magnetic Stimulation
2.5 Mechanisms of Action of TMS
2.6 Efficacy of TMS in Depression
2.7 Neuroimaging Studies on TMS in Depression
2.8 Safety and Side Effects of TMS
2.9 Factors Influencing TMS Response
2.10 Gaps in the Literature

Chapter 3: Research Methodology
3.1 Research Design
3.2 Participants
3.3 Procedure
3.4 Data Collection
3.5 Data Analysis
3.6 Measures
3.7 Ethical Considerations
3.8 Validity and Reliability
3.9 Limitations of the Methodology

Chapter 4: Discussion of Findings
4.1 Overview of the Study
4.2 Description of the Sample
4.3 Analysis of Results
4.4 Comparison with Previous Studies
4.5 Implications for Clinical Practice
4.6 Recommendations for Future Research

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Conclusions
5.3 Clinical Implications
5.4 Limitations of the Study
5.5 Future Directions
5.6 Final Thoughts

This thesis will provide a comprehensive overview of the effects of transcranial magnetic stimulation on treatment-resistant depression, exploring the current state of knowledge, identifying gaps in the literature, and offering insights for future research and clinical practice. By shedding light on this innovative treatment modality, this study aims to contribute to the ongoing efforts to improve outcomes for individuals with TRD.

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