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INTRODUCTION

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from defects in insulin secretion, insulin action, or both. It is a growing public health concern worldwide, with an estimated 422 million adults living with diabetes in 2014, according to the World Health Organization. Antidiabetic drug therapy plays a crucial role in the management of diabetes, aiming to control blood glucose levels, prevent complications, and improve quality of life for patients.

Recent advances in antidiabetic drug therapy have significantly expanded the treatment options available for diabetes management, providing patients with more personalized and effective treatment regimens. These advances include the development of new classes of antidiabetic drugs, such as SGLT2 inhibitors, GLP-1 receptor agonists, and DPP-4 inhibitors, as well as the introduction of biosimilar insulins and insulin analogs. Additionally, advancements in technology, such as continuous glucose monitoring systems and insulin pumps, have improved the monitoring and delivery of insulin therapy.

This thesis aims to explore the recent advances in antidiabetic drug therapy and their implications for diabetes management. The following chapters will provide a comprehensive review of the literature, the research methodology used, the discussion of findings, and the conclusion and summary of the project.

TABLE OF CONTENTS

CHAPTER 1: INTRODUCTION
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

CHAPTER 2: LITERATURE REVIEW
2.1 Overview of Diabetes Mellitus
2.2 Traditional Antidiabetic Drugs
2.3 Advances in Antidiabetic Drug Therapy
2.4 SGLT2 Inhibitors
2.5 GLP-1 Receptor Agonists
2.6 DPP-4 Inhibitors
2.7 Biosimilar Insulins
2.8 Insulin Analogs
2.9 Continuous Glucose Monitoring Systems
2.10 Insulin Pumps

CHAPTER 3: RESEARCH METHODOLOGY
3.1 Research Design
3.2 Sampling
3.3 Data Collection
3.4 Data Analysis
3.5 Ethical Considerations
3.6 Research Limitations
3.7 Research Validity
3.8 Research Reliability

CHAPTER 4: DISCUSSION OF FINDINGS
4.1 Overview of Findings
4.2 Comparison of Antidiabetic Drug Classes
4.3 Efficacy and Safety of New Antidiabetic Drugs
4.4 Patient Adherence and Outcomes
4.5 Cost-effectiveness of Antidiabetic Drug Therapy
4.6 Future Directions in Antidiabetic Drug Development

CHAPTER 5: CONCLUSION AND SUMMARY
5.1 Summary of Findings
5.2 Conclusion
5.3 Implications for Clinical Practice
5.4 Recommendations for Future Research
5.5 Contributions to the Field

THESIS OVERVIEW

Advances in Antidiabetic Drug Therapy have revolutionized the management of diabetes, offering patients a wider range of treatment options to achieve glycemic control and prevent long-term complications. This thesis explores the recent developments in antidiabetic drug therapy, including the introduction of new classes of drugs, such as SGLT2 inhibitors, GLP-1 receptor agonists, and DPP-4 inhibitors, as well as the use of biosimilar insulins and insulin analogs.

The literature review delves into the traditional antidiabetic drugs and the advancements in drug therapy, highlighting the efficacy, safety, and cost-effectiveness of these new treatment options. The research methodology outlines the design, sampling, data collection, and analysis methods used in the study, ensuring the validity and reliability of the findings.

The discussion of findings provides an overview of the comparative effectiveness of different antidiabetic drug classes, patient adherence and outcomes, and the future directions in drug development. The conclusion and summary chapter summarize the key findings, implications for clinical practice, recommendations for future research, and contributions to the field.

Overall, this thesis contributes to the growing body of knowledge on Advances in Antidiabetic Drug Therapy, offering insights into the latest developments in diabetes management and the potential impact on patient care.

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