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Introduction

Optogenetics is a cutting-edge technology that combines genetic engineering and optics to control the activity of specific neurons in living tissue. It has revolutionized the field of neuroscience by allowing researchers to manipulate neural circuits with unprecedented precision. One area of research that has benefited greatly from optogenetics is the study of decision-making processes in the brain.

Decision confidence refers to the subjective feeling of certainty or uncertainty that accompanies a decision. Understanding how the brain computes decision confidence is crucial for unraveling the mechanisms underlying complex cognitive processes, such as economic decision-making and social interactions. Optogenetic tools offer a unique opportunity to investigate the neural basis of decision confidence by selectively activating or inhibiting specific neural populations involved in this computation.

This thesis aims to explore the use of optogenetic modulation to manipulate decision confidence in animal models. By targeting key brain regions implicated in decision-making processes, we hope to elucidate the neural circuits that underlie the computation of decision confidence. The findings of this study may have implications for understanding the neural basis of confidence-related disorders, such as anxiety and obsessive-compulsive disorder.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Historical development of optogenetics
2.2 Neural circuits involved in decision-making
2.3 Computational models of decision confidence
2.4 Applications of optogenetics in neuroscience
2.5 Studies on decision confidence using optogenetic modulation

Chapter 3: Research Methodology
3.1 Selection of animal models
3.2 Optogenetic tools and techniques
3.3 Target brain regions for modulation
3.4 Experimental design
3.5 Data collection and analysis
3.6 Ethical considerations
3.7 Statistical methods
3.8 Validation of results

Chapter 4: Discussion of Findings
4.1 Effects of optogenetic modulation on decision confidence
4.2 Neural circuits implicated in decision confidence
4.3 Comparison with previous studies
4.4 Implications for neural computation
4.5 Future directions for research

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field of neuroscience
5.3 Limitations of the study
5.4 Recommendations for future research

Thesis Overview

The overarching goal of this thesis is to investigate the role of optogenetic modulation in manipulating decision confidence in animal models. By targeting specific neural circuits involved in decision-making processes, we aim to uncover the neural mechanisms underlying the computation of decision confidence. The thesis will begin with a comprehensive review of the literature on optogenetics, decision-making, and decision confidence. This will provide the theoretical framework for the subsequent chapters on research methodology and findings. The discussion section will analyze the results of the experiments and compare them to previous studies in the field. Finally, the conclusion will summarize the key findings, discuss their implications, and suggest directions for future research. Through this research, we hope to contribute to a better understanding of decision confidence and its neural underpinnings.

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