Repurposing existing drugs for rare diseases – Complete Phd and Masters Thesis

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Introduction

Rare diseases are often characterized by their lack of effective treatment options due to limited research and financial resources. Repurposing existing drugs for rare diseases has emerged as a promising strategy to expedite the drug development process and provide new treatment options for patients with these conditions. This approach involves identifying, evaluating, and repurposing existing drugs that have already been approved for other indications, thus bypassing many of the challenges associated with traditional drug development.

This thesis aims to explore the potential of repurposing existing drugs for rare diseases, focusing on the opportunities and challenges associated with this approach. By analyzing the current literature, research methodologies, and findings in this field, this thesis aims to provide valuable insights into the feasibility and implications of repurposing existing drugs for rare diseases.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Rare Diseases
2.2 Traditional Drug Development Process
2.3 Repurposing Existing Drugs: Concept and Definitions
2.4 Advantages of Drug Repurposing
2.5 Challenges of Drug Repurposing
2.6 Case Studies of Successful Drug Repurposing
2.7 Regulatory and Ethical Considerations
2.8 Economic Implications
2.9 Future Directions in Drug Repurposing
2.10 Gaps in Current Literature

Chapter 3: Research Methodology
3.1 Research Design
3.2 Data Collection Methods
3.3 Data Analysis Techniques
3.4 Sample Selection Criteria
3.5 Inclusion and Exclusion Criteria
3.6 Variables and Measurements
3.7 Ethical Considerations
3.8 Limitations of Research Methodology

Chapter 4: Discussion of Findings
4.1 Overview of Findings
4.2 Analysis of Data
4.3 Comparison with Existing Literature
4.4 Implications for Clinical Practice
4.5 Recommendations for Future Research
4.6 Strengths and Limitations of Study
4.7 Conclusions

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Practice
5.3 Recommendations for Policy and Research
5.4 Limitations of the Study
5.5 Future Directions
5.6 Concluding Remarks

Thesis Overview: Repurposing existing drugs for rare diseases

Repurposing existing drugs for rare diseases is a novel approach that holds significant promise for addressing the unmet medical needs of patients with rare conditions. This thesis will provide a comprehensive analysis of the opportunities and challenges associated with drug repurposing, utilizing a combination of a literature review, research methodology, and discussion of findings. By examining the current state of research in this field, this thesis aims to contribute to the growing body of knowledge on drug repurposing and offer insights into its potential impact on rare disease treatment and drug development strategies.

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