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Introduction

Epigenetics is the study of changes in gene expression or cellular phenotype that do not involve alterations in the underlying DNA sequence. Epigenetic regulators, such as DNA methyltransferases, histone deacetylases, and histone methyltransferases, play a crucial role in the regulation of gene expression and have been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

The development of drugs targeting epigenetic regulators has emerged as a promising strategy for the treatment of these diseases. These drugs work by modulating the activity of epigenetic regulators, thereby restoring normal gene expression patterns and potentially reversing disease states. However, the development of such drugs poses several challenges, including target specificity, toxicity, and off-target effects.

This thesis aims to provide a comprehensive overview of the current state of research on the development of drugs targeting epigenetic regulators. The following chapters will discuss the background of the study, the problem statement, the objectives of the study, the limitations and scope of the study, the significance of the study, and the structure of the thesis. Additionally, key terms relevant to the topic will be defined in Chapter 1.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of epigenetic regulation
2.2 Current strategies for targeting epigenetic regulators
2.3 Clinical applications of drugs targeting epigenetic regulators
2.4 Challenges in the development of epigenetic drugs
2.5 Mechanisms of action of epigenetic drugs
2.6 Epigenetic regulators as therapeutic targets
2.7 Examples of epigenetic drugs in clinical trials
2.8 Combination therapies involving epigenetic drugs
2.9 Future directions in epigenetic drug development
2.10 Conclusion

Chapter 3: Research Methodology
3.1 Research design
3.2 Selection of study participants
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Validity and reliability of the study
3.7 Limitations of the study
3.8 Scope of the study

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Comparison with existing literature
4.3 Implications of findings
4.4 Recommendations for future research
4.5 Limitations of the study
4.6 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Practical implications
5.4 Recommendations for further research
5.5 Conclusion

Overall, this thesis will provide valuable insights into the development of drugs targeting epigenetic regulators and contribute to the advancement of this promising field in therapeutics.

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