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**Introduction**

Diabetes is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It is a major public health concern worldwide, with an estimated 422 million adults living with diabetes in 2014. The management of diabetes involves lifestyle modifications such as diet and exercise, as well as the use of pharmacological agents to control blood glucose levels. Anti-diabetic drugs play a crucial role in the management of diabetes by helping to improve insulin sensitivity, increase insulin secretion, and reduce glucose production in the liver.

**Table of Contents**

1.1 Introduction

1.2 Background of Study

1.3 Problem Statement

1.4 Objective of Study

1.5 Limitation of Study

1.6 Scope of Study

1.7 Significance of Study

1.8 Structure of the Thesis

1.9 Definition of Terms

**Chapter Two: Literature Review**

2.1 Overview of Diabetes Mellitus

2.2 Mechanisms of Action of Anti-Diabetic Drugs

2.3 Classification of Anti-Diabetic Drugs

2.4 Efficacy and Safety of Anti-Diabetic Drugs

2.5 Current Trends in the Management of Diabetes

2.6 Adherence to Anti-Diabetic Therapy

2.7 Drug Interactions with Anti-Diabetic Drugs

2.8 Future Perspectives in Anti-Diabetic Drug Development

2.9 Role of Pharmacogenetics in Anti-Diabetic Therapy

2.10 Economic Burden of Diabetes and Cost-effectiveness of Anti-Diabetic Therapy

**Chapter Three: Research Methodology**

3.1 Research Design

3.2 Study Population

3.3 Sampling Techniques

3.4 Data Collection Methods

3.5 Data Analysis Methods

3.6 Ethical Considerations

3.7 Statistical Analysis

3.8 Research Limitations

**Chapter Four: Discussion of Findings**

4.1 Overview of Study Findings

4.2 Comparative Analysis of Anti-Diabetic Drugs

4.3 Adverse Effects of Anti-Diabetic Drugs

4.4 Drug Interactions and Contradictions

4.5 Impact of Pharmacogenetics on Anti-Diabetic Therapy

4.6 Patient Adherence to Anti-Diabetic Therapy

4.7 Recommendations for Clinical Practice

4.8 Implications for Future Research

**Chapter Five: Conclusion and Summary**

5.1 Summary of Key Findings

5.2 Conclusion

5.3 Recommendations for Practice

5.4 Recommendations for Future Research

In conclusion, this thesis aims to provide a comprehensive overview of the pharmacology of anti-diabetic drugs, including their mechanisms of action, efficacy, safety, and impact on patient outcomes. Through a thorough literature review and research methodology, this study seeks to contribute to the current understanding of diabetes management and inform clinical practice and future research in this field.

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