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Introduction

Alzheimer’s disease is a neurodegenerative disorder that affects millions of individuals worldwide, resulting in cognitive decline and memory loss. One of the early symptoms of Alzheimer’s disease is the impairment of spatial navigation abilities, which can greatly impact an individual’s daily functioning and quality of life. Neuroimaging techniques have been increasingly used to study the neural mechanisms underlying spatial navigation deficits in Alzheimer’s disease, providing valuable insights into the pathophysiology of the disease. This thesis aims to investigate the role of neuroimaging in understanding spatial navigation impairments in Alzheimer’s disease, with the goal of improving early detection and developing targeted interventions for individuals affected by the disease.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Alzheimer’s disease
2.2 Spatial navigation deficits in Alzheimer’s disease
2.3 Neuroimaging techniques in Alzheimer’s disease research
2.4 Structural neuroimaging studies of spatial navigation in Alzheimer’s disease
2.5 Functional neuroimaging studies of spatial navigation in Alzheimer’s disease
2.6 Combined structural and functional neuroimaging studies in Alzheimer’s disease
2.7 Role of neural networks in spatial navigation deficits in Alzheimer’s disease
2.8 Neuroimaging biomarkers for early detection of Alzheimer’s disease
2.9 Challenges and future directions in neuroimaging research of spatial navigation in Alzheimer’s disease
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Neuroimaging techniques
3.4 Spatial navigation tasks
3.5 Data analysis
3.6 Ethical considerations
3.7 Pilot study
3.8 Validation study
3.9 Reliability analysis
3.10 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Structural neuroimaging findings
4.2 Functional neuroimaging findings
4.3 Combined structural and functional neuroimaging findings
4.4 Neural network abnormalities in Alzheimer’s disease
4.5 Neuroimaging biomarkers for early detection
4.6 Implications for diagnosis and treatment
4.7 Comparison with existing literature
4.8 Limitations of the study
4.9 Future research directions
4.10 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview on Neuroimaging of Spatial Navigation in Alzheimer’s Disease

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and spatial navigation impairments. This thesis aims to investigate the role of neuroimaging techniques in understanding the neural mechanisms underlying spatial navigation deficits in Alzheimer’s disease. The literature review will provide an overview of Alzheimer’s disease, spatial navigation deficits, and neuroimaging techniques used in research. The research methodology will outline the study design, participant selection, neuroimaging techniques, spatial navigation tasks, and data analysis procedures. The discussion of findings will present and interpret the results of structural and functional neuroimaging studies, neural network abnormalities, neuroimaging biomarkers, and implications for diagnosis and treatment. The conclusion will summarize the findings, discuss implications for clinical practice, provide recommendations for future research, and conclude the thesis.

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