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Introduction:

Lewy body dementia (LBD) is a complex and progressive neurodegenerative disorder that affects cognitive function, motor skills, and behavior. One of the key features of LBD is the presence of abnormal protein deposits called Lewy bodies in the brain. These Lewy bodies are thought to play a role in the development of the disease, but the exact mechanisms underlying their formation and progression are not fully understood.

Neurovascular changes have been proposed as a potential contributing factor to the development and progression of LBD. The brain is highly dependent on a constant supply of oxygen and nutrients delivered through cerebral blood vessels. Any disruption to this delicate balance can have profound effects on brain function and health. Understanding how neurovascular changes contribute to the pathogenesis of LBD could provide insights into new therapeutic targets and strategies for managing the disease.

This thesis aims to explore the relationship between neurovascular changes and Lewy body dementia. The following chapters will provide a comprehensive review of the existing literature on this topic, outline the research methodology used in this study, analyze the findings, and discuss their implications. By shedding light on the role of neurovascular changes in LBD, this thesis seeks to contribute to our understanding of the disease and potentially pave the way for new avenues of research and treatment.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Lewy body dementia
2.2 Neurovascular changes in neurodegenerative diseases
2.3 The role of blood-brain barrier dysfunction in LBD
2.4 Cerebral blood flow regulation in LBD
2.5 Vascular risk factors for LBD
2.6 Imaging techniques for studying neurovascular changes in LBD
2.7 Neuroinflammation and vascular dysfunction in LBD
2.8 Therapeutic strategies targeting neurovascular changes in LBD
2.9 Gaps in current knowledge and future research directions

Chapter 3: Research Methodology
3.1 Research design
3.2 Participant selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Research limitations
3.7 Validity and reliability
3.8 Data interpretation

Chapter 4: Discussion of Findings
4.1 Overview of study results
4.2 Neurovascular changes observed in LBD
4.3 Relationship between neurovascular changes and disease progression
4.4 Comparison with existing literature
4.5 Implications for future research and clinical practice
4.6 Study strengths and limitations

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Practical implications
5.4 Recommendations for future research
5.5 Conclusion

This thesis aims to provide a comprehensive overview of the current state of knowledge on neurovascular changes in Lewy body dementia, with the ultimate goal of advancing our understanding of the disease and identifying potential avenues for therapeutic intervention. Through a combination of literature review, research methodology, and data analysis, this study seeks to shed light on the complex relationship between neurovascular changes and LBD, and their impact on disease progression and management.

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