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Introduction

The rise of multi-drug resistant bacteria poses a significant threat to public health worldwide. Antibiotics have been a cornerstone in the treatment of bacterial infections for decades, but the emergence of resistance has led to a decrease in the effectiveness of these drugs. In this thesis, we will explore the development of new antibiotics to combat multi-drug resistant bacteria and address the challenges associated with this process.

Chapter 1: Introduction

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review

2.1 History of antibiotics
2.2 Mechanisms of antibiotic resistance
2.3 Current challenges in antibiotic development
2.4 Novel approaches to antibiotic discovery
2.5 Natural sources of antibiotics
2.6 Synthetic antibiotics
2.7 Antibiotic combination therapy
2.8 Pharmacokinetics and pharmacodynamics of antibiotics
2.9 Clinical trials of new antibiotics
2.10 Regulatory issues in antibiotic development

Chapter 3: Research Methodology

3.1 Research design
3.2 Sampling techniques
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Budget and timeline
3.7 Risk assessment
3.8 Validity and reliability of findings

Chapter 4: Discussion of Findings

4.1 In vitro studies of new antibiotics
4.2 Animal model studies of new antibiotics
4.3 Clinical trials results
4.4 Comparison with existing antibiotics
4.5 Adverse effects and drug interactions
4.6 Resistance mechanisms to new antibiotics
4.7 Future directions for antibiotic development
4.8 Policy implications

Chapter 5: Conclusion and Summary

In conclusion, the development of new antibiotics to combat multi-drug resistant bacteria is a critical area of research that requires collaboration between scientists, clinicians, regulatory agencies, and policymakers. This thesis aims to contribute to the existing knowledge in this field and provide insights for future research and development efforts.

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