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Introduction

Drug-induced liver injury (DILI) is a major concern in the field of pharmacology and drug development, as it can lead to severe liver damage and even death in some cases. Understanding the biochemical mechanisms behind DILI is crucial for the identification of potential risk factors and the development of preventive measures. This thesis aims to explore the different biochemical pathways involved in DILI and their implications for drug safety.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of drug-induced liver injury
2.2 Biochemical mechanisms of DILI
2.3 Risk factors for DILI
2.4 Current strategies for DILI prevention and management
2.5 Animal models for studying DILI
2.6 Genetic factors in DILI susceptibility
2.7 Role of inflammation in DILI
2.8 Drug metabolism and DILI
2.9 Biomarkers for DILI
2.10 Future directions in DILI research

Chapter 3: Research Methodology
3.1 Research design
3.2 Sample selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Experimental procedures
3.7 Statistical analysis
3.8 Quality control measures

Chapter 4: Discussion of Findings
4.1 Biochemical pathways involved in DILI
4.2 Impact of drug metabolism on DILI risk
4.3 Role of inflammation in DILI progression
4.4 Genetic factors influencing DILI susceptibility
4.5 Biomarkers for early detection of DILI
4.6 Comparison of different animal models for studying DILI
4.7 Implications of research findings for drug safety
4.8 Suggestions for future research directions

Chapter 5: Conclusion and Summary
In this final chapter, the key findings of the study will be summarized, and the implications for clinical practice and drug development will be discussed. The limitations of the study will be acknowledged, and recommendations for further research in this field will be provided.

Thesis Overview
Drug-induced liver injury is a serious and potentially life-threatening condition that can result from the use of various medications and dietary supplements. It is a complex and multifactorial process, involving a range of biochemical mechanisms that can lead to liver damage. This thesis aims to provide a comprehensive overview of the current understanding of the biochemical pathways involved in drug-induced liver injury, with a focus on the risk factors, prevention strategies, and management approaches for this condition. By exploring the existing literature and conducting original research, this thesis seeks to contribute to the growing body of knowledge on DILI and provide insights that can inform clinical practice and drug development efforts.

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