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Introduction

Drug repurposing, also known as drug repositioning, is the process of identifying new therapeutic uses for existing drugs that are already approved for other indications. This approach offers several advantages, including reduced development costs, accelerated approval timelines, and potentially improved patient outcomes. In the context of rare cardiovascular disorders, where limited treatment options are available, drug repurposing holds great promise for addressing unmet medical needs.

This thesis aims to explore the potential of drug repurposing for rare cardiovascular disorders, focusing on identifying existing drugs that may be effective in treating these conditions. By leveraging the wealth of existing knowledge on drug safety and efficacy, researchers can expedite the development of new treatments for rare cardiovascular disorders, ultimately improving patient outcomes and quality of life.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
– Overview of rare cardiovascular disorders
– Current treatment options for rare cardiovascular disorders
– Drug repurposing strategies
– Successful examples of drug repurposing in cardiovascular diseases
– Challenges and limitations of drug repurposing in cardiovascular disorders
– Regulatory considerations for drug repurposing
– Patient perspectives on drug repurposing for rare cardiovascular disorders
– Economic implications of drug repurposing in cardiovascular diseases
– Future directions in drug repurposing for rare cardiovascular disorders
– Ethical considerations in drug repurposing research

Chapter 3: Research Methodology
– Study design and rationale
– Data collection methods
– Drug screening and selection criteria
– In vitro and in vivo validation strategies
– Statistical analysis plan
– Ethical considerations and approval
– Study limitations and biases
– Timeline and project management

Chapter 4: Discussion of Findings
– Identification of potential repurposed drugs for rare cardiovascular disorders
– Mechanistic insights into drug efficacy in rare cardiovascular disorders
– Comparison of repurposed drugs with existing treatment options
– Implications for clinical practice and patient care
– Future research directions and opportunities

Chapter 5: Conclusion and Summary
– Summary of key findings
– Implications for drug repurposing in rare cardiovascular disorders
– Recommendations for clinical practice
– Limitations and future research directions
– Concluding remarks

In conclusion, this thesis aims to shed light on the potential of drug repurposing in addressing unmet medical needs in the field of rare cardiovascular disorders. By exploring existing drugs for new therapeutic uses, researchers can accelerate the development of treatments for these conditions and improve patient outcomes. This research has the potential to make a significant impact on the field of cardiovascular medicine and improve the lives of patients with rare cardiovascular disorders.

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