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Introduction

BRAF inhibitors have revolutionized the treatment of BRAF-mutant melanoma, leading to significant improvements in patient outcomes. However, the development of resistance to these inhibitors remains a major challenge in the field of oncology. This thesis aims to explore novel approaches to overcome resistance to BRAF inhibitors, with the ultimate goal of improving treatment outcomes for patients with BRAF-mutant melanoma.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of BRAF-mutant melanoma
2.2 Mechanisms of resistance to BRAF inhibitors
2.3 Current treatment strategies for BRAF inhibitor resistance
2.4 Targeted therapy combination approaches
2.5 Immunotherapy strategies
2.6 Emerging targeted therapies
2.7 Preclinical and clinical studies on novel approaches to overcome resistance
2.8 Promising experimental strategies
2.9 Future directions in the field
2.10 Gaps in current knowledge

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Validity and reliability of the study
3.7 Potential biases
3.8 Research limitations

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Comparison with existing literature
4.3 Implications for clinical practice
4.4 Future research directions
4.5 Limitations of the study
4.6 Strengths of the study
4.7 Recommendations for further research

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Limitations of the study
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview on Novel Approaches to Overcome BRAF Inhibitor Resistance

BRAF inhibitors have shown great promise in the treatment of BRAF-mutant melanoma, but the development of resistance remains a significant challenge. This thesis aims to explore novel approaches to overcome resistance to BRAF inhibitors in order to improve treatment outcomes for patients with this aggressive form of cancer.

In chapter one, the introduction provides a background of the study, the problem statement, objectives, limitations, scope, significance, and structure of the thesis. Chapter two outlines the current literature on BRAF-mutant melanoma, mechanisms of resistance, current treatment strategies, targeted therapy combinations, immunotherapy approaches, and emerging targeted therapies. Chapter three details the research methodology, including design, population, data collection, analysis, ethical considerations, validity, reliability, and limitations.

Chapter four delves into the discussion of findings, including an overview, comparison with existing literature, clinical implications, future directions, study limitations, strengths, and recommendations for further research. Finally, chapter five offers a conclusion and summary of key findings, implications for clinical practice, limitations, recommendations for future research, and a final conclusion.

Through this thesis, novel approaches to overcome BRAF inhibitor resistance will be explored, with the ultimate goal of improving treatment outcomes for patients with BRAF-mutant melanoma.

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