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Introduction

In the field of cancer research, the use of Poly (ADP-ribose) polymerase (PARP) inhibitors as a targeted therapy has shown great promise in the treatment of various types of cancers, particularly those with BRCA mutations. However, despite the initial success of PARP inhibitors, the development of resistance to these drugs has become a significant challenge in clinical practice. To address this issue, novel approaches to overcome PARP inhibitor resistance are urgently needed. This thesis aims to explore and evaluate these novel approaches in order to improve the effectiveness of PARP inhibitor therapy in cancer treatment.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of PARP inhibitors and their mechanism of action
2.2 Resistance mechanisms to PARP inhibitors
2.3 Current strategies to overcome PARP inhibitor resistance
2.4 Emerging novel approaches to overcome PARP inhibitor resistance
2.5 Synthetic lethality in cancer therapy
2.6 Targeting DNA repair pathways in PARP inhibitor resistance
2.7 Combination therapy with other targeted agents
2.8 Immunotherapy strategies in overcoming PARP inhibitor resistance
2.9 Clinical trials evaluating novel approaches to overcome PARP inhibitor resistance
2.10 Future directions in the field of PARP inhibitor resistance research

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethics considerations
3.6 Research limitations
3.7 Validity and reliability of research findings
3.8 Research implications
3.9 Recommendations for future research

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Analysis of novel approaches to overcome PARP inhibitor resistance
4.3 Comparison of different strategies in addressing PARP inhibitor resistance
4.4 Implications for clinical practice
4.5 Challenges and limitations of novel approaches
4.6 Future directions in research on PARP inhibitor resistance
4.7 Contribution to the field of cancer therapy
4.8 Recommendations for further research
4.9 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to the field of cancer research
5.3 Implications for clinical practice
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview on Novel Approaches to Overcome PARP Inhibitor Resistance

Poly (ADP-ribose) polymerase (PARP) inhibitors have revolutionized the treatment of cancer, particularly in patients with BRCA mutations. However, the development of resistance to these inhibitors presents a major challenge in clinical practice. This thesis aims to explore novel approaches to overcome PARP inhibitor resistance and improve the efficacy of cancer therapy.

Chapter 1 provides an overview of the research topic, including the background, problem statement, objectives, limitations, scope, significance, and structure of the thesis. It also defines key terms related to PARP inhibitors and resistance mechanisms.

In Chapter 2, a comprehensive literature review is conducted to examine the current understanding of PARP inhibitors, resistance mechanisms, existing strategies, and emerging novel approaches to overcome resistance. The chapter also discusses clinical trials and future directions in this field.

Chapter 3 outlines the research methodology, including the study design, population, data collection, analysis techniques, ethics considerations, limitations, and recommendations for future research.

Chapter 4 presents a detailed discussion of the research findings, analyzing the effectiveness of novel approaches in addressing PARP inhibitor resistance, comparing different strategies, discussing implications for clinical practice, and highlighting challenges and future research directions.

Finally, Chapter 5 provides a summary of key findings, contributions to the field, implications for clinical practice, recommendations for future research, and a conclusion. Overall, this thesis aims to advance our understanding of PARP inhibitor resistance and provide valuable insights for improving cancer therapy outcomes.

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