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Introduction:

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by repetitive, involuntary movements and vocalizations known as tics. While the exact etiology of TS remains unclear, current research suggests that it may involve dysfunction in various neurotransmitter systems, such as dopamine and serotonin, as well as abnormalities in brain regions involved in motor control and inhibition. Current treatments for TS, such as dopamine antagonists and behavioral therapies, only provide symptomatic relief and have limited efficacy in managing the disorder. Therefore, there is an urgent need to identify novel targets for therapeutic intervention in TS.

This thesis aims to explore novel targets for the treatment of TS, with a focus on identifying potential molecular pathways and brain regions that may be involved in the pathophysiology of the disorder. By elucidating the underlying mechanisms of TS, this research aims to provide insights into potential novel targets for the development of more effective and targeted therapies for TS patients.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Tourette syndrome
2.2 Current treatment options for TS
2.3 Neurotransmitter systems implicated in TS
2.4 Brain regions involved in TS
2.5 Genetic factors in TS
2.6 Animal models of TS
2.7 Novel targets for TS treatment identified in previous studies
2.8 Challenges in developing novel therapies for TS
2.9 Summary of current knowledge on novel targets in TS

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Pilot study
3.7 Validity and reliability of findings
3.8 Limitations of the study

Chapter 4: Discussion of Findings
4.1 Novel targets identified in the study
4.2 Potential mechanisms of action of novel targets
4.3 Implications for the treatment of TS
4.4 Future directions for research on novel targets in TS
4.5 Comparison of novel targets with current treatment options
4.6 Challenges in translating novel targets to clinical practice
4.7 Limitations of the study
4.8 Strengths of the study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Limitations of the study
5.5 Concluding remarks

Thesis Overview:

Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by involuntary movements and vocalizations known as tics. Current treatments for TS are limited in their efficacy, and there is a need for novel targets for therapeutic intervention. This thesis aims to explore novel targets for the treatment of TS by investigating potential molecular pathways and brain regions involved in the pathophysiology of the disorder. The literature review will provide an overview of current knowledge on TS, including neurotransmitter systems, brain regions, genetic factors, and animal models of the disorder. The research methodology will outline the design, population, data collection, analysis techniques, and ethical considerations of the study. The discussion of findings will present novel targets identified in the study, potential mechanisms of action, implications for treatment, and future research directions. The conclusion will summarize key findings, provide recommendations for clinical practice and future research, and discuss limitations of the study. This thesis aims to contribute to the understanding of TS and identify novel targets for the development of more effective therapies for TS patients.

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