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Introduction

Resistance to ALK inhibitors is a major challenge in the treatment of ALK-positive non-small cell lung cancer (NSCLC). Despite the initial success of ALK inhibitors in improving patient outcomes, the development of resistance mechanisms limits their long-term efficacy. Novel approaches to overcome ALK inhibitor resistance are urgently needed to improve patient outcomes and prolong survival. This thesis aims to explore novel strategies to overcome ALK inhibitor resistance in NSCLC.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Mechanisms of ALK inhibitor resistance
2.2 Targeted therapies for ALK-positive NSCLC
2.3 Emerging therapies for ALK inhibitor resistance
2.4 Combination therapy approaches
2.5 Immune checkpoint inhibitors in ALK-positive NSCLC
2.6 Liquid biopsies for monitoring resistance
2.7 Novel drug delivery systems
2.8 Resistance mechanisms in brain metastases
2.9 Role of the tumor microenvironment in resistance
2.10 Future directions in ALK inhibitor resistance research

Chapter 3: Research Methodology
3.1 Study design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Statistical analysis
3.7 Biomarker assessment
3.8 In vitro and in vivo models

Chapter 4: Discussion of Findings
4.1 Resistance mechanisms identified
4.2 Efficacy of novel therapeutic approaches
4.3 Clinical implications of study findings
4.4 Comparison with existing literature
4.5 Limitations of the study
4.6 Future directions for research
4.7 Implications for clinical practice
4.8 Recommendations for further study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview

Novel approaches to overcome ALK inhibitor resistance in NSCLC are essential for improving patient outcomes and prolonging survival. This thesis will explore the mechanisms of resistance to ALK inhibitors, current targeted therapies, emerging treatment strategies, and future directions in ALK inhibitor resistance research. The literature review will examine the role of combination therapy, immune checkpoint inhibitors, liquid biopsies, drug delivery systems, and the tumor microenvironment in overcoming resistance. The research methodology section will detail the study design, population, data collection methods, and analytical techniques used to investigate novel therapeutic approaches in ALK-positive NSCLC. The discussion of findings will present the results of the study, including identified resistance mechanisms, efficacy of novel therapies, and implications for clinical practice. The conclusion will summarize key findings, provide recommendations for future research, and discuss the potential impact of novel approaches on patient care.

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