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Introduction

Stevens-Johnson syndrome (SJS) is a rare but severe hypersensitivity reaction that primarily affects the skin and mucous membranes. It is considered a medical emergency, as it can lead to significant morbidity and mortality if not promptly diagnosed and treated. Drug-induced SJS is a subset of cases where the syndrome is triggered by a medication. In recent years, there has been a growing interest in identifying biomarkers that can predict and diagnose drug-induced SJS, as well as guide treatment decisions.

This thesis aims to explore the current understanding of drug-induced SJS biomarkers, with a focus on their potential utility in clinical practice. By reviewing the existing literature and conducting original research, this study seeks to contribute to the development of personalized medicine approaches for patients at risk of developing this life-threatening condition.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Drug-induced Stevens-Johnson syndrome
2.2 Pathophysiology of Stevens-Johnson syndrome
2.3 Biomarkers in drug-induced hypersensitivity reactions
2.4 Genetic factors influencing drug-induced SJS
2.5 Immunological markers in drug-induced SJS
2.6 Clinical manifestations of drug-induced SJS
2.7 Diagnostic approaches for drug-induced SJS
2.8 Treatment strategies for drug-induced SJS
2.9 Prognostic biomarkers in drug-induced SJS
2.10 Challenges in biomarker research for drug-induced SJS

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Biomarker selection criteria
3.5 Statistical analysis plan
3.6 Ethical considerations
3.7 Data interpretation strategies
3.8 Quality assurance measures

Chapter 4: Discussion of Findings
4.1 Summary of research findings
4.2 Comparison with existing literature
4.3 Implications for clinical practice
4.4 Future research directions
4.5 Limitations of the study
4.6 Strengths of the study
4.7 Practical applications of the research
4.8 Recommendations for healthcare providers

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to the field
5.3 Implications for personalized medicine
5.4 Study limitations
5.5 Future research directions
5.6 Conclusion and final remarks

Thesis Overview: Drug-induced Stevens-Johnson syndrome (SJS) is a severe and potentially life-threatening hypersensitivity reaction that can be triggered by certain medications. The identification of biomarkers that can predict and diagnose drug-induced SJS is crucial for improving patient outcomes and guiding treatment decisions. This thesis aims to review the current literature on drug-induced SJS biomarkers and conduct original research to contribute to the development of personalized medicine approaches for this condition. The study will include a comprehensive literature review, research methodology, discussion of findings, and conclusion and summary sections. By enhancing our understanding of drug-induced SJS biomarkers, this research has the potential to inform clinical practice and improve the management of patients at risk of developing this serious adverse drug reaction.

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