Drug delivery systems for miRNA therapeutics – Complete Phd and Masters Thesis

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Introduction

In recent years, microRNA (miRNA) therapeutics have gained significant attention for their potential in treating various diseases, including cancer, cardiovascular disorders, and neurological diseases. However, the successful delivery of miRNA therapeutics to target cells remains a significant challenge due to their inherent instability and poor pharmacokinetics. Drug delivery systems play a crucial role in overcoming these challenges by ensuring the efficient and targeted delivery of miRNA therapeutics to specific cells or tissues.

This thesis focuses on exploring various drug delivery systems for miRNA therapeutics and their potential applications in medicine. The following chapters will delve into the background of the study, problem statement, objectives, limitations, scope, significance, and structure of the thesis, followed by a literature review, research methodology, discussion of findings, and conclusion.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of the Study
1.3 Problem Statement
1.4 Objectives of the Study
1.5 Limitations of the Study
1.6 Scope of the Study
1.7 Significance of the Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of miRNA Therapeutics
2.2 Challenges in miRNA Delivery
2.3 Types of Drug Delivery Systems
2.4 Lipid-Based Delivery Systems
2.5 Polymer-Based Delivery Systems
2.6 Nanoparticle-Based Delivery Systems
2.7 Exosome-Based Delivery Systems
2.8 Challenges and Opportunities in Drug Delivery Systems for miRNA Therapeutics
2.9 Current Developments in the Field
2.10 Future Perspectives

Chapter 3: Research Methodology
3.1 Research Design
3.2 Data Collection Methods
3.3 Data Analysis Techniques
3.4 Sample Population
3.5 Experimental Procedures
3.6 Variables
3.7 Ethical Considerations
3.8 Pilot Study

Chapter 4: Discussion of Findings
4.1 Efficacy of Different Drug Delivery Systems
4.2 Targeted Delivery Approaches
4.3 Mechanisms of Action
4.4 In Vivo Studies
4.5 Safety and Toxicity Considerations
4.6 Regulatory Challenges
4.7 Commercialization Potential
4.8 Future Directions

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Clinical Practice
5.3 Recommendations for Future Research
5.4 Conclusion

Thesis Overview

MicroRNAs (miRNAs) are small non-coding RNAs that play key regulatory roles in gene expression and have been implicated in various diseases, including cancer, cardiovascular disorders, and neurological diseases. The use of miRNA therapeutics holds great promise for the development of novel treatment strategies, but their successful translation into clinical practice requires efficient drug delivery systems to overcome biological barriers and ensure targeted delivery to specific cells or tissues.

This thesis aims to provide a comprehensive overview of drug delivery systems for miRNA therapeutics, with a focus on their design, mechanisms of action, efficacy, safety, and potential applications in medicine. Through a thorough review of the literature, analysis of current developments, and discussion of research findings, this thesis seeks to contribute to the growing body of knowledge in the field and guide future research and development efforts in drug delivery systems for miRNA therapeutics.

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