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Introduction:

Addiction is a complex and chronic brain disorder characterized by compulsive drug seeking and use, despite harmful consequences. Despite extensive research on the neurobiological mechanisms underlying addiction, the specific molecular pathways and mechanisms that contribute to vulnerability or resilience to addiction remain poorly understood. One emerging area of research that holds promise in shedding light on these mechanisms is epigenetics, the study of changes in gene expression that do not involve alterations in the DNA sequence.

Epigenetic modifications such as DNA methylation, histone modifications, and non-coding RNA-mediated gene regulation have been shown to play a crucial role in regulating gene expression in response to environmental stimuli, including exposure to drugs of abuse. This thesis aims to explore the role of epigenetic regulation in addiction-related behaviors, with a focus on how epigenetic changes influence vulnerability to addiction, the development of addictive behaviors, and potential treatment approaches.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Introduction to addiction and epigenetics
2.2 Epigenetic mechanisms involved in addiction
2.3 Role of DNA methylation in addiction
2.4 Histone modifications in addiction
2.5 Non-coding RNAs in addiction
2.6 Epigenetic regulation of neurotransmitter systems in addiction
2.7 Epigenetic mechanisms in addiction vulnerability and resilience
2.8 Epigenetic changes in brain reward pathways
2.9 Epigenetic markers of addiction
2.10 Epigenetic therapies for addiction

Chapter 3: Research Methodology
3.1 Research design
3.2 Participant selection
3.3 Data collection methods
3.4 Epigenetic assays
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Validity and reliability
3.8 Data analysis procedures

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Epigenetic changes associated with addiction-related behaviors
4.3 Implications for addiction research and treatment
4.4 Future directions
4.5 Comparison with existing literature
4.6 Limitations of the study
4.7 Recommendations for further research

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for addiction research and treatment
5.3 Contribution to the field of epigenetics in addiction
5.4 Conclusion
5.5 Future directions

Overall, this thesis will provide a comprehensive overview of the current state of knowledge on the epigenetic regulation of addiction-related behaviors, with implications for understanding addiction vulnerability, developing new treatment approaches, and advancing the field of addiction research.

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