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Introduction

DNA repair is a crucial process that maintains the integrity of the genome and ensures the survival of cells in response to DNA damage. Dysfunction in DNA repair can lead to accumulation of mutations, genomic instability, and ultimately, the development of various diseases including cancer. Pharmacological modulation of DNA repair has emerged as a promising strategy to enhance the efficacy of DNA damaging agents used in cancer therapy, and to overcome resistance to DNA damaging agents in cancer cells.

This thesis aims to provide a comprehensive overview of the current knowledge on pharmacological modulation of DNA repair, with a focus on its potential applications in cancer therapy. The thesis will explore the various pathways involved in DNA repair, the mechanisms by which pharmacological agents can modulate these pathways, and the potential clinical implications of targeting DNA repair in cancer treatment.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of DNA repair pathways
2.2 Role of DNA repair in cancer
2.3 Pharmacological modulation of DNA repair
2.4 DNA repair inhibitors
2.5 DNA repair enhancers
2.6 Combination therapy targeting DNA repair
2.7 Clinical trials targeting DNA repair
2.8 Challenges in targeting DNA repair
2.9 Future perspectives
2.10 Conclusion

Chapter 3: Research Methodology
3.1 Research design
3.2 Selection of pharmacological agents
3.3 Cell culture experiments
3.4 Assessment of DNA repair activity
3.5 Statistical analysis
3.6 In vivo studies
3.7 Drug delivery strategies
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Effects of pharmacological modulation on DNA repair
4.2 Mechanisms of action of pharmacological agents
4.3 Synergistic effects of combination therapy
4.4 Resistance mechanisms to DNA repair inhibitors
4.5 Clinical implications of targeting DNA repair
4.6 Comparison of different DNA repair inhibitors
4.7 Future directions in pharmacological modulation of DNA repair

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for cancer therapy
5.3 Limitations of the study
5.4 Future research directions

In conclusion, this thesis aims to provide a comprehensive understanding of the role of pharmacological modulation of DNA repair in cancer therapy. By exploring the various pathways involved in DNA repair, the mechanisms by which pharmacological agents can modulate these pathways, and the potential clinical implications of targeting DNA repair in cancer treatment, this thesis will contribute to the development of novel strategies for enhancing the efficacy of cancer therapy.

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