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Introduction

Neurovascular changes in mild cognitive impairment have gained significant attention in the field of neurology and cognitive neuroscience due to the increasing prevalence of cognitive decline and dementia among older adults. Mild cognitive impairment (MCI) is a common condition characterized by subtle cognitive deficits that are greater than expected for age, but do not significantly interfere with daily functioning. Individuals with MCI are at an increased risk of developing Alzheimer’s disease or other forms of dementia, making early detection and intervention crucial.

This thesis aims to explore the neurovascular changes that occur in individuals with MCI, with a focus on understanding the underlying mechanisms and their implications for cognitive function. By investigating the relationship between neurovascular changes and cognitive decline in MCI, this study seeks to contribute to the growing body of knowledge on the pathophysiology of cognitive impairment and potential therapeutic targets.

Chapter One: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
2.1 Theoretical framework of neurovascular changes in MCI
2.2 Neuroimaging studies of neurovascular changes in MCI
2.3 Neuroinflammatory mechanisms in MCI
2.4 Vascular risk factors for cognitive decline
2.5 Cognitive reserve theory and neurovascular changes
2.6 Pharmacological interventions targeting neurovascular changes
2.7 Non-pharmacological interventions for neurovascular changes
2.8 Genetic factors influencing neurovascular changes in MCI
2.9 Neurovascular changes in different subtypes of MCI
2.10 Gaps in current understanding of neurovascular changes in MCI

Chapter Three: Research Methodology
3.1 Research design
3.2 Participant selection
3.3 Data collection procedures
3.4 Neuroimaging assessments
3.5 Cognitive assessment measures
3.6 Statistical analysis plan
3.7 Ethical considerations
3.8 Timelines and budget

Chapter Four: Discussion of Findings
4.1 Neurovascular changes in individuals with MCI
4.2 Relationship between neurovascular changes and cognitive function
4.3 Implications for clinical practice
4.4 Future research directions
4.5 Comparisons with existing literature
4.6 Limitations of the study
4.7 Strengths of the study
4.8 Recommendations for healthcare providers and policymakers

Chapter Five: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for practice
5.4 Limitations of the study
5.5 Future research directions
5.6 Concluding remarks

Thesis Overview on Neurovascular changes in mild cognitive impairment

Neurovascular changes in mild cognitive impairment (MCI) have emerged as a critical area of research due to the increasing prevalence of cognitive decline and dementia in the aging population. This thesis aims to investigate the neurovascular changes that occur in individuals with MCI, with a focus on understanding the underlying mechanisms and their implications for cognitive function.

Chapter One provides an introduction to the topic, outlining the background of the study, problem statement, research objectives, study limitations, scope, significance, structure of the thesis, and definition of key terms. Chapter Two presents a comprehensive literature review on neurovascular changes in MCI, covering theoretical frameworks, neuroimaging studies, neuroinflammatory mechanisms, vascular risk factors, cognitive reserve theory, pharmacological and non-pharmacological interventions, genetic factors, subtypes of MCI, and gaps in current knowledge.

Chapter Three details the research methodology, including research design, participant selection, data collection procedures, neuroimaging and cognitive assessments, statistical analysis plan, ethical considerations, and timelines. Chapter Four discusses the findings of the study, focusing on neurovascular changes in individuals with MCI, the relationship between neurovascular changes and cognitive function, implications for clinical practice, future research directions, comparisons with existing literature, limitations, and recommendations.

Chapter Five presents the conclusion and summary of the thesis, summarizing key findings, contributions to the field, implications for practice, limitations, future research directions, and concluding remarks. Overall, this thesis aims to advance our understanding of neurovascular changes in MCI and contribute to the development of targeted interventions for cognitive impairment in older adults.

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