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Introduction

Epilepsy is a neurological disorder characterized by recurrent seizures that affect millions of people worldwide. Despite extensive research on the pathophysiology of epilepsy, the exact mechanisms underlying seizure initiation and propagation remain unclear. Neurovascular coupling, the process by which neural activity is matched with cerebral blood flow, has emerged as a key player in the pathogenesis of epilepsy. Understanding the intricate interplay between neuronal activity and vascular responses is crucial for developing targeted therapies for epilepsy.

Chapter 1: Introduction
1.1 The Introduction
1.2 Background of the Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
– Overview of Epilepsy and Neurovascular Coupling
– Neuroimaging studies in epilepsy
– Animal models of epilepsy
– Role of neurotransmitters in neurovascular coupling
– Genetic factors in epilepsy
– Neuroinflammation and neurovascular coupling
– Pharmacological interventions targeting neurovascular coupling
– Clinical implications of neurovascular coupling in epilepsy
– Future directions in research on neurovascular coupling

Chapter 3: Research Methodology
– Study design
– Participant selection criteria
– Data collection methods
– Data analysis techniques
– Ethical considerations
– Statistical analysis
– Quality control measures
– Data interpretation

Chapter 4: Discussion of Findings
– Neurovascular coupling alterations in epilepsy
– Impact of seizures on neurovascular coupling
– Relationship between neuronal activity and cerebral blood flow
– Pharmacological modulation of neurovascular coupling
– Implications for epilepsy management
– Comparison with existing literature
– Limitations of the study
– Future research directions

Chapter 5: Conclusion and Summary
– Summary of key findings
– Implications for clinical practice
– Recommendations for further research
– Conclusion

Thesis Overview:

Neurovascular coupling refers to the tight coordination between neural activity and cerebral blood flow, which is essential for maintaining normal brain function. In epilepsy, disruptions in this coupling mechanism have been implicated in the pathogenesis of seizure generation and propagation. This thesis aims to explore the role of neurovascular coupling in epilepsy, with a focus on understanding how alterations in this process contribute to the development and progression of seizures.

The literature review will provide a comprehensive overview of current research on neurovascular coupling in epilepsy, including neuroimaging studies, animal models, and clinical implications. The research methodology section will outline the study design, participant selection criteria, data collection methods, and data analysis techniques used in this study.

The discussion of findings will delve into the specific alterations in neurovascular coupling observed in epilepsy, the impact of seizures on this process, and potential pharmacological interventions targeting neurovascular coupling. The conclusion will summarize the key findings of the study, discuss their implications for clinical practice, and provide recommendations for future research in this area. Overall, this thesis aims to shed light on the complex relationship between neurovascular coupling and epilepsy, with the ultimate goal of improving our understanding and management of this debilitating disorder.

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