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Introduction

Obesity is a growing public health concern worldwide, with significant implications for the pharmacokinetics of drugs. Pharmacokinetics, the study of how drugs are absorbed, distributed, metabolized, and excreted in the body, plays a crucial role in determining the efficacy and safety of drug therapy in obese individuals.

This thesis aims to explore the impact of obesity on the pharmacokinetics of drugs, with a focus on understanding how altered physiological and metabolic pathways in obese individuals can influence drug disposition. By gaining a deeper understanding of these mechanisms, we can improve drug dosing strategies and optimize therapeutic outcomes in this population.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Obesity and drug metabolism
2.2 Pharmacokinetic changes in obesity
2.3 Effects of obesity on drug absorption
2.4 Distribution of drugs in obese individuals
2.5 Metabolism of drugs in obesity
2.6 Excretion of drugs in obese individuals
2.7 Pharmacokinetic studies in obese populations
2.8 Drug dosing considerations in obesity
2.9 Pharmacokinetic modeling in obesity
2.10 Future directions in pharmacokinetics research in obesity

Chapter 3: Research Methodology
3.1 Study design
3.2 Sample selection
3.3 Data collection
3.4 Data analysis
3.5 Ethical considerations
3.6 Statistical methods
3.7 Study limitations
3.8 Validation of methods

Chapter 4: Discussion of Findings
4.1 Impact of obesity on drug absorption
4.2 Altered drug distribution in obese individuals
4.3 Metabolic changes affecting drug metabolism
4.4 Drug excretion in obesity
4.5 Dosing considerations in obese patients
4.6 Pharmacokinetic modeling in obesity
4.7 Clinical implications of pharmacokinetic changes in obesity
4.8 Future research directions

Chapter 5: Conclusion and Summary
Summary of key findings
Implications for clinical practice
Recommendations for future research
Conclusion

Thesis Overview:
Obesity is a complex metabolic condition that affects the pharmacokinetics of drugs in various ways. This thesis aims to provide a comprehensive analysis of the impact of obesity on drug absorption, distribution, metabolism, and excretion, with a focus on optimizing drug therapy in obese individuals. By reviewing the existing literature, conducting original research, and discussing the findings in detail, this thesis will contribute to the growing body of knowledge on pharmacokinetics of drugs in obesity. It is hoped that the insights gained from this study will inform clinical practice and improve therapeutic outcomes for obese patients.

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