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Introduction

Histone modifications and non-coding RNA biology play crucial roles in gene regulation and epigenetic control of cellular processes. These two areas of study have gained significant attention in recent years due to their implications in various diseases, including cancer, neurodevelopmental disorders, and metabolic diseases. Understanding the mechanisms underlying histone modifications and non-coding RNA biology is essential for elucidating the complex regulatory networks that govern gene expression.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Histone modifications
2.2 Types of histone modifications
2.3 Role of histone modifications in gene regulation
2.4 Non-coding RNAs: an overview
2.5 Classification of non-coding RNAs
2.6 Regulatory roles of non-coding RNAs
2.7 Crosstalk between histone modifications and non-coding RNAs
2.8 Impact of histone modifications and non-coding RNAs in disease
2.9 Therapeutic targeting of histone modifications and non-coding RNAs
2.10 Current challenges and future directions in the field

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Experimental techniques for studying histone modifications
3.6 Experimental techniques for studying non-coding RNAs
3.7 Bioinformatics tools for data analysis
3.8 Ethical considerations in research

Chapter 4: Discussion of Findings
4.1 Correlation between histone modifications and non-coding RNAs
4.2 Impact of histone modifications and non-coding RNAs on gene expression
4.3 Role of histone modifications and non-coding RNAs in disease pathogenesis
4.4 Therapeutic implications of targeting histone modifications and non-coding RNAs
4.5 Future directions in research on histone modifications and non-coding RNAs

Chapter 5: Conclusion and Summary
In this chapter, the key findings of the thesis will be summarized, and conclusions drawn from the research will be discussed. Recommendations for future research in the field of histone modifications and non-coding RNA biology will also be provided.

Thesis Overview on Histone Modifications and Non-coding RNA Biology

Histone modifications and non-coding RNA biology are two areas of research that have revolutionized our understanding of gene regulation and epigenetic control. Histone modifications refer to chemical changes in histone proteins that can alter chromatin structure and gene expression. Non-coding RNAs, on the other hand, are a diverse group of RNA molecules that do not code for proteins but play essential roles in gene regulation.

The interplay between histone modifications and non-coding RNAs is highly complex and tightly regulated. Both epigenetic mechanisms work together to fine-tune gene expression in response to various environmental stimuli and developmental cues. Dysregulation of histone modifications and non-coding RNAs has been implicated in numerous diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders.

This thesis aims to provide a comprehensive overview of the current understanding of histone modifications and non-coding RNA biology. The literature review will cover the different types of histone modifications and non-coding RNAs, their regulatory roles in gene expression, and the crosstalk between these two epigenetic mechanisms. The research methodology section will outline the experimental techniques and bioinformatics tools used to study histone modifications and non-coding RNAs. The discussion of findings will delve into the implications of histone modifications and non-coding RNAs in disease pathogenesis and the potential therapeutic strategies targeting these epigenetic mechanisms.

Overall, this thesis will contribute to the growing body of knowledge in the field of histone modifications and non-coding RNA biology and provide insights into the potential applications of targeting these epigenetic mechanisms in disease prevention and treatment.

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