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Introduction

The intricate relationship between neurobiology, neurovascular coupling, and the blood-brain barrier plays a crucial role in maintaining the homeostasis of the central nervous system. Neurovascular coupling refers to the tight coupling between neural activity and the regulation of cerebral blood flow, while the blood-brain barrier serves as a selective barrier that regulates the passage of molecules and ions between the blood and the brain. Understanding the mechanisms underlying neurovascular coupling and the blood-brain barrier is essential for elucidating the pathophysiology of various neurological disorders and developing targeted therapeutic interventions.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Neurovascular coupling in healthy brain
2.2 Regulation of cerebral blood flow
2.3 Blood-brain barrier structure and function
2.4 Neurovascular coupling in neurodegenerative diseases
2.5 Neurovascular coupling in stroke
2.6 Role of inflammation in disrupting neurovascular coupling
2.7 Current therapeutic approaches targeting neurovascular coupling
2.8 Molecular mechanisms underlying neurovascular coupling
2.9 Imaging techniques to study neurovascular coupling
2.10 Future directions in neurovascular coupling research

Chapter 3: Research Methodology
3.1 Study design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis procedures
3.5 Ethical considerations
3.6 Measurement of cerebral blood flow
3.7 Assessment of blood-brain barrier integrity
3.8 Neuroimaging techniques

Chapter 4: Discussion of Findings
4.1 Neurovascular coupling abnormalities in neurological disorders
4.2 Implications for therapeutic interventions
4.3 Challenges and limitations of current research
4.4 Future research directions
4.5 The role of neuroinflammation in neurovascular coupling dysfunction

Chapter 5: Conclusion and Summary
In conclusion, the understanding of neurovascular coupling and blood-brain barrier function is essential for unraveling the complex mechanisms underlying brain health and disease. This thesis aims to provide a comprehensive overview of the current knowledge in the field and highlights the importance of further research in this area. By elucidating the molecular and cellular mechanisms governing neurovascular coupling and blood-brain barrier integrity, we can pave the way for the development of novel treatment strategies for neurological disorders.

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