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Thesis Overview: Exploring the Role of Extracellular Vesicles in the Pathogenesis of Osteoarthritis

Introduction

Osteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of cartilage and inflammation of the joints, leading to pain and disability. Despite being a common condition affecting millions of people worldwide, the exact mechanisms underlying OA pathogenesis are not fully understood. Recently, there has been growing interest in the role of extracellular vesicles (EVs) in the development and progression of OA. EVs are small membrane-bound particles released by cells that contain a variety of molecules, including proteins, lipids, and nucleic acids, which can influence cell-to-cell communication and disease processes. This thesis aims to explore the role of EVs in the pathogenesis of OA and their potential as diagnostic and therapeutic targets.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Osteoarthritis
2.2 Pathogenesis of Osteoarthritis
2.3 Extracellular Vesicles: Biogenesis and Functions
2.4 Role of Extracellular Vesicles in Inflammatory Processes
2.5 Extracellular Vesicles in Joint Diseases
2.6 Current Diagnostic Approaches in Osteoarthritis
2.7 Therapeutic Strategies for Osteoarthritis
2.8 EVs as Biomarkers for Osteoarthritis
2.9 EV-based Therapies for Osteoarthritis
2.10 Gaps in Knowledge and Future Directions

Chapter 3: Research Methodology
3.1 Study Design
3.2 Participant Selection Criteria
3.3 Sample Collection and Processing
3.4 EV Isolation and Characterization
3.5 RNA and Protein Analysis
3.6 Functional Assays
3.7 Statistical Analysis
3.8 Ethical Considerations

Chapter 4: Discussion of Findings
4.1 Characterization of EVs in Osteoarthritis
4.2 EV Cargo and Its Role in OA Pathogenesis
4.3 Differential Expression of EV Components in OA Patients
4.4 Functional Effects of OA-derived EVs on Target Cells
4.5 Comparison of EVs in OA Progression
4.6 Diagnostic Potential of EV Biomarkers
4.7 Therapeutic Targeting of EV Pathways
4.8 Implications for Future Research

Chapter 5: Conclusion
5.1 Summary of Findings
5.2 Implications for Clinical Practice
5.3 Future Research Directions
5.4 Limitations of the Study
5.5 Conclusion

Through an in-depth analysis of the current literature and original research findings, this thesis aims to provide a comprehensive overview of the role of extracellular vesicles in the pathogenesis of osteoarthritis. By elucidating the mechanisms by which EVs contribute to disease development and progression, this study seeks to contribute to the development of novel diagnostic and therapeutic strategies for OA patients.

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