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Introduction:

The development of orally disintegrating tablets (ODTs) has gained significant attention in recent years due to their convenience and ease of administration, particularly for pediatric and geriatric patients. ODTs have become a popular dosage form as they provide a quick disintegration and dissolution in the mouth, eliminating the need for water. This characteristic is particularly beneficial for patients who may have difficulty swallowing conventional tablets or require a more convenient dosage form.

Biopharmaceutical characterization of ODTs is essential to ensure their safety, efficacy, and quality for pediatric and geriatric patients. Understanding the biopharmaceutical properties of these tablets, including their disintegration and dissolution profiles, is crucial for optimizing drug delivery and patient outcomes. This thesis aims to investigate the biopharmaceutical characteristics of ODTs for pediatric and geriatric drugs, with a focus on enhancing drug delivery and patient compliance.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of the study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of orally disintegrating tablets
2.2 Biopharmaceutical properties of ODTs
2.3 Drug delivery challenges in pediatric and geriatric patients
2.4 Formulation strategies for ODTs
2.5 Regulatory considerations for pediatric and geriatric drugs
2.6 Clinical studies on ODTs in pediatric and geriatric patients
2.7 Patient acceptability and compliance with ODTs
2.8 Stability and shelf-life of ODTs
2.9 Emerging technologies in ODT development
2.10 Gaps in current knowledge

Chapter 3: Research Methodology
3.1 Study design
3.2 Selection of drugs for study
3.3 Formulation and characterization of ODTs
3.4 In vitro dissolution studies
3.5 In vivo pharmacokinetic studies
3.6 Patient acceptability assessments
3.7 Statistical analysis
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Biopharmaceutical characterization of ODTs
4.2 Influence of formulation on drug release
4.3 Pharmacokinetic profiles of ODT drugs
4.4 Comparison with conventional dosage forms
4.5 Patient acceptability and compliance
4.6 Safety and tolerability of ODTs
4.7 Regulatory implications
4.8 Future directions for research

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for pediatric and geriatric drug delivery
5.3 Recommendations for clinical practice
5.4 Limitations and future research directions

Thesis Overview:

The aim of this thesis is to investigate the biopharmaceutical characterization of orally disintegrating tablets (ODTs) for pediatric and geriatric drugs. The introduction provides a background to the study, highlighting the importance of ODTs in improving drug delivery for these patient populations. The literature review explores current research on ODTs, formulation strategies, regulatory considerations, and patient acceptability. The research methodology outlines the study design, drug selection, formulation, and characterization of ODTs, as well as in vitro and in vivo studies. The discussion of findings evaluates the biopharmaceutical properties of ODTs, formulation influence on drug release, pharmacokinetic profiles, patient acceptability, and safety. The conclusion summarizes key findings, implications for drug delivery, recommendations for clinical practice, and future research directions. Ultimately, this thesis aims to contribute to the field of pediatric and geriatric drug delivery by enhancing the understanding of ODT biopharmaceutical characteristics.

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