Exploring the role of metabolic reprogramming in the development and progression of Huntingtonʼs disease – Complete Phd and Masters Thesis

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Introduction:

Huntington’s disease is a devastating neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. Despite extensive research, the underlying mechanisms of this disease remain poorly understood. Recent studies have suggested that metabolic reprogramming, the process by which cells alter their metabolic pathways to support proliferation and survival, may play a crucial role in the development and progression of Huntington’s disease. This thesis aims to explore the role of metabolic reprogramming in the pathogenesis of Huntington’s disease, with the goal of identifying potential therapeutic targets to slow or halt the progression of the disease.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Huntington’s Disease
2.2 Metabolic Reprogramming in Neurodegenerative Diseases
2.3 Role of Mitochondrial Dysfunction in Huntington’s Disease
2.4 Altered Glucose Metabolism in Huntington’s Disease
2.5 Dysregulated Lipid Metabolism in Huntington’s Disease
2.6 Impact of Metabolic Reprogramming on Huntington’s Disease Progression
2.7 Therapeutic Strategies Targeting Metabolic Reprogramming
2.8 Current Challenges in Metabolic Reprogramming Research
2.9 Future Directions in Metabolic Reprogramming Studies
2.10 Summary of Literature Review

Chapter 3: Research Methodology
3.1 Study Design
3.2 Participants
3.3 Data Collection Methods
3.4 Data Analysis Techniques
3.5 Ethical Considerations
3.6 Validity and Reliability
3.7 Limitations of the Study
3.8 Conclusion on Methodology

Chapter 4: Discussion of Findings
4.1 Overview of Study Results
4.2 Analysis of Metabolic Reprogramming in Huntington’s Disease
4.3 Implications of Findings
4.4 Comparison with Existing Literature
4.5 Strengths and Limitations of the Study
4.6 Future Research Directions
4.7 Conclusion on Findings

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Huntington’s Disease Research
5.3 Contributions to the Field
5.4 Recommendations for Clinical Practice
5.5 Conclusion

Thesis Overview:

Huntington’s disease is a devastating neurodegenerative disorder for which there is currently no cure. Recent research has implicated metabolic reprogramming in the development and progression of the disease, offering new avenues for therapeutic intervention. This thesis aims to explore the role of metabolic reprogramming in Huntington’s disease, with a specific focus on how altered metabolism may contribute to the pathogenesis of the disease. By conducting a comprehensive literature review, analyzing data from research studies, and discussing the implications of the findings, this thesis seeks to shed light on the potential mechanisms driving Huntington’s disease and identify new opportunities for treatment development. The research methodology section will outline the study design, participant selection, data collection methods, and data analysis techniques used in the investigation. The discussion of findings section will present an in-depth analysis of the results, compare the findings with existing literature, and propose future research directions. The conclusion and summary section will summarize the key findings, discuss the implications for Huntington’s disease research, and provide recommendations for clinical practice. Ultimately, this thesis aims to contribute to our understanding of Huntington’s disease and provide insights into potential therapeutic targets for the treatment of this devastating disorder.

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