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Introduction

Candida albicans is a common fungal pathogen that can cause infections ranging from superficial mucosal infections to life-threatening systemic infections in immunocompromised individuals. The increasing prevalence of drug resistance in C. albicans poses a significant challenge to the effective treatment of Candida infections. Understanding the molecular mechanisms underlying drug resistance in C. albicans is crucial for developing new strategies to combat this problem and improve the efficacy of antifungal therapy.

This thesis aims to investigate the molecular basis of drug resistance in C. albicans and its implications for antifungal therapy. By elucidating the mechanisms by which C. albicans develops resistance to antifungal drugs, we hope to identify potential targets for the development of novel antifungal agents and treatment strategies.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Candida albicans infections
2.2 Antifungal drugs and mechanisms of action
2.3 Mechanisms of drug resistance in Candida albicans
2.4 Genetic factors contributing to drug resistance
2.5 Epigenetic regulation of drug resistance
2.6 Role of efflux pumps in drug resistance
2.7 Biofilm formation and drug resistance
2.8 Combination therapy for drug-resistant Candida infections
2.9 Emerging therapies for drug-resistant Candida infections
2.10 Future directions in antifungal therapy

Chapter 3: Research Methodology
3.1 Study design
3.2 Selection of study subjects
3.3 Sample collection and processing
3.4 Molecular techniques for studying drug resistance
3.5 Data analysis methods
3.6 Statistical analysis
3.7 Ethical considerations
3.8 Quality control measures

Chapter 4: Discussion of Findings
4.1 Characterization of drug-resistant Candida isolates
4.2 Identification of molecular mechanisms underlying drug resistance
4.3 Implications for antifungal therapy
4.4 Comparison with existing literature
4.5 Limitations of the study
4.6 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Concluding remarks

In conclusion, this thesis aims to provide valuable insights into the molecular basis of drug resistance in C. albicans and its implications for antifungal therapy. By elucidating the mechanisms by which C. albicans develops resistance to antifungal drugs, we hope to contribute to the development of new and more effective treatment strategies for Candida infections.

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