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Introduction

Psoriasis is a chronic inflammatory skin disease affecting approximately 2-3% of the global population. It is characterized by red, scaly patches on the skin that can be itchy and painful, leading to significant impact on quality of life. Current treatments for psoriasis include topical therapies, phototherapy, and systemic medications such as biologics. However, these treatments are not always effective for all patients and may have side effects or limitations.

In recent years, small molecule inhibitors have emerged as a promising approach for the treatment of psoriasis. These compounds target specific pathways involved in the pathogenesis of the disease, offering the potential for improved efficacy and safety compared to existing therapies. One such novel small molecule inhibitor is currently under investigation for the treatment of psoriasis, with early preclinical studies showing promising results.

This thesis aims to evaluate the efficacy and safety of this novel small molecule inhibitor for the treatment of psoriasis. The research will involve preclinical and clinical studies to assess the drug’s mechanism of action, pharmacokinetics, efficacy in reducing psoriatic symptoms, and safety profile in patients with psoriasis.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Psoriasis
2.2 Current Treatment Landscape
2.3 Small Molecule Inhibitors in Psoriasis
2.4 Mechanism of Action of Novel Inhibitor
2.5 Efficacy of Novel Inhibitor in Preclinical Studies
2.6 Safety Profile of Novel Inhibitor
2.7 Clinical Trials of Novel Inhibitor
2.8 Adverse Events and Tolerability
2.9 Future Directions
2.10 Gaps in Knowledge

Chapter 3: Research Methodology
3.1 Study Design
3.2 Subject Selection Criteria
3.3 Drug Administration Protocol
3.4 Outcome Measures
3.5 Data Collection and Analysis
3.6 Ethical Considerations
3.7 Statistical Analysis
3.8 Sample Size Calculation

Chapter 4: Discussion of Findings
4.1 Mechanism of Action
4.2 Pharmacokinetics
4.3 Efficacy in Reducing Psoriatic Symptoms
4.4 Safety Profile
4.5 Comparison with Existing Therapies
4.6 Adherence and Tolerability
4.7 Patient Satisfaction
4.8 Implications for Clinical Practice

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Conclusions
5.3 Clinical Implications
5.4 Limitations of the Study
5.5 Future Directions
5.6 Recommendations

Thesis Overview

Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. Current treatments, while effective for many patients, have limitations such as side effects or lack of efficacy in some individuals. Small molecule inhibitors have shown promise as a novel approach to treating psoriasis, with a potential for improved efficacy and safety compared to existing therapies.

This thesis aims to evaluate the efficacy and safety of a novel small molecule inhibitor for the treatment of psoriasis. Through preclinical and clinical studies, the research will investigate the drug’s mechanism of action, pharmacokinetics, efficacy in reducing psoriatic symptoms, and safety profile in patients with psoriasis.

The literature review will provide an overview of psoriasis, current treatment landscape, and the use of small molecule inhibitors in psoriasis. It will also discuss the mechanism of action of the novel inhibitor, preclinical and clinical studies, safety profile, and future directions for research.

The research methodology section will detail the study design, subject selection criteria, drug administration protocol, outcome measures, data collection and analysis, ethical considerations, statistical analysis, and sample size calculation.

The discussion of findings will explore the mechanism of action of the novel inhibitor, pharmacokinetics, efficacy in reducing psoriatic symptoms, safety profile, comparison with existing therapies, adherence and tolerability, patient satisfaction, and implications for clinical practice.

In conclusion, this thesis will summarize the findings, draw conclusions, discuss clinical implications, highlight limitations of the study, suggest future directions for research, and make recommendations for the use of the novel small molecule inhibitor in the treatment of psoriasis.

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