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Introduction

The kidneys play a crucial role in the excretion of drugs and their metabolites from the body. However, drug-induced nephrotoxicity remains a significant concern in clinical practice, leading to acute kidney injury and chronic kidney disease. MicroRNAs, small non-coding RNAs that regulate gene expression, have emerged as key regulators of various cellular processes, including drug metabolism and nephrotoxicity. This thesis aims to explore the role of microRNAs in the regulation of drug-induced nephrotoxicity, with the ultimate goal of identifying potential therapeutic targets for the prevention and treatment of kidney damage.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of drug-induced nephrotoxicity
2.2 Role of microRNAs in kidney function
2.3 MicroRNAs in drug metabolism
2.4 MicroRNAs as biomarkers of nephrotoxicity
2.5 Mechanisms of drug-induced nephrotoxicity
2.6 Current therapies for drug-induced nephrotoxicity
2.7 MicroRNAs as therapeutic targets in kidney diseases
2.8 Animal models of drug-induced nephrotoxicity
2.9 MicroRNAs and drug-induced nephrotoxicity in clinical studies
2.10 Gaps in the current literature

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 MicroRNA profiling techniques
3.5 Bioinformatics analysis
3.6 Cell culture experiments
3.7 Animal studies
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 MicroRNAs dysregulated in drug-induced nephrotoxicity
4.2 Potential mechanisms of microRNA-mediated nephrotoxicity
4.3 Therapeutic implications of microRNAs in drug-induced nephrotoxicity
4.4 Comparison with existing literature
4.5 Implications for future research
4.6 Limitations of the study
4.7 Strengths of the study
4.8 Recommendations for clinical practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field of nephrotoxicity research
5.3 Future directions for research
5.4 Conclusion

Thesis Overview

Drug-induced nephrotoxicity is a significant clinical problem that can lead to acute kidney injury and chronic kidney disease. MicroRNAs have emerged as important regulators of drug metabolism and kidney function, but their role in drug-induced nephrotoxicity remains underexplored. This thesis aims to investigate the role of microRNAs in the regulation of drug-induced nephrotoxicity and identify potential therapeutic targets for kidney protection. The literature review will provide a comprehensive overview of the current knowledge in the field, while the research methodology will outline the experimental approaches used in the study. The discussion of findings will present the results of the study, including dysregulated microRNAs and potential mechanisms of nephrotoxicity. Finally, the conclusion will summarize the key findings and suggest future directions for research in this area.

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