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Introduction

Tuberculosis (TB) remains a major global health challenge with approximately 10 million new cases and 1.5 million deaths reported in 2018. One of the major obstacles in the effective treatment of TB is the emergence of drug-resistant strains of the causative agent, Mycobacterium tuberculosis. Drug resistance in TB is a multifactorial phenomenon involving both genetic and environmental factors. Understanding the molecular basis of drug resistance is crucial for the development of new strategies for combating this deadly disease.

This thesis aims to investigate the molecular basis of drug resistance in TB and its implications for antibiotic therapy. By elucidating the mechanisms by which TB bacteria develop resistance to commonly used antibiotics, we hope to identify potential targets for the development of novel therapies. Furthermore, understanding the evolution of drug-resistant TB strains will provide valuable insights into the dynamics of antibiotic resistance in bacterial populations.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Historical perspectives on TB treatment
2.2 Mechanisms of drug resistance in TB
2.3 Genetic determinants of drug resistance
2.4 Molecular mechanisms of antibiotic action
2.5 Evolutionary dynamics of drug resistance
2.6 Current treatment strategies for drug-resistant TB
2.7 Novel therapeutic approaches for drug-resistant TB
2.8 Diagnostic challenges in drug-resistant TB
2.9 Global impact of drug-resistant TB
2.10 Future directions in TB research

Chapter 3: Research Methodology
3.1 Study design
3.2 Sample collection and preparation
3.3 Molecular techniques for drug resistance profiling
3.4 Bioinformatic analysis of genetic data
3.5 In vitro drug susceptibility testing
3.6 Animal models of drug-resistant TB
3.7 Statistical analysis
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Genetic determinants of drug resistance in clinical isolates
4.2 Evolutionary trajectories of drug-resistant TB strains
4.3 Mechanisms of drug resistance in experimental models
4.4 Implications for antibiotic therapy
4.5 Challenges and opportunities for drug development
4.6 Public health implications of drug-resistant TB
4.7 Policy recommendations for TB control
4.8 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Concluding remarks

Thesis Overview

Tuberculosis (TB) is a major global health threat, with drug-resistant strains of Mycobacterium tuberculosis posing a significant challenge to effective treatment. This thesis aims to investigate the molecular basis of drug resistance in TB and its implications for antibiotic therapy. The introduction provides a background on TB, drug resistance, and the rationale for the study. The literature review examines historical perspectives, mechanisms of drug resistance, and current treatment strategies. The research methodology outlines the study design, data collection, and analysis. The discussion of findings presents the results of genetic, evolutionary, and mechanistic studies on drug-resistant TB. The conclusion summarizes the key findings, discusses their implications, and provides recommendations for future research. Overall, this thesis contributes to our understanding of drug resistance in TB and provides insights for the development of novel therapeutic strategies.

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