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Introduction

Alzheimer’s disease is a progressive neurodegenerative disorder that currently has no cure. The blood-brain barrier presents a significant challenge for drug delivery to the brain, limiting the effectiveness of traditional drug therapies. Exosomes, small extracellular vesicles secreted by cells, have emerged as a promising drug delivery system due to their ability to cross biological barriers and deliver therapeutic cargo to target cells. This thesis aims to investigate the potential of exosome-based drug delivery systems for the treatment of Alzheimerʼs disease.

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter Two: Literature Review
2.1 Introduction to Alzheimer’s disease
2.2 Current treatment options and challenges
2.3 Exosomes as drug delivery vehicles
2.4 Mechanisms of exosome uptake by recipient cells
2.5 Exosome-based therapies for neurodegenerative diseases
2.6 Studies on exosome-mediated drug delivery for Alzheimer’s disease
2.7 Challenges and limitations of exosome-based drug delivery systems
2.8 Future directions and potential applications
2.9 Summary of literature review

Chapter Three: Research Methodology
3.1 Research design
3.2 Study population
3.3 Selection of exosome source
3.4 Isolation and characterization of exosomes
3.5 Loading exosomes with therapeutic cargo
3.6 Evaluation of exosome uptake by neuronal cells
3.7 Assessment of therapeutic efficacy in in vitro models
3.8 Statistical analysis

Chapter Four: Discussion of Findings
4.1 Exosome isolation and characterization
4.2 Loading efficiency of exosomes with therapeutic cargo
4.3 Uptake of exosomes by neuronal cells
4.4 Therapeutic efficacy of exosome-based drug delivery systems
4.5 Comparison with traditional drug delivery methods
4.6 Limitations and challenges encountered
4.7 Implications of findings for Alzheimer’s disease treatment
4.8 Future research directions

Chapter Five: Conclusion and Summary
5.1 Recap of research objectives
5.2 Summary of key findings
5.3 Implications for clinical practice
5.4 Recommendations for future research
5.5 Conclusion

Thesis overview on Investigating the potential of exosome-based drug delivery systems for the treatment of Alzheimerʼs disease:

Alzheimer’s disease is a devastating neurodegenerative disorder with no cure. The blood-brain barrier poses a challenge for drug delivery to the brain, hindering the effectiveness of traditional therapies. Exosomes, small vesicles secreted by cells, have emerged as a promising drug delivery system due to their ability to cross biological barriers and deliver therapeutic cargo. This thesis investigates the potential of exosome-based drug delivery systems for the treatment of Alzheimer’s disease. The literature review covers current treatment options, the role of exosomes in drug delivery, and studies on exosome-mediated therapies for neurodegenerative diseases. The research methodology involves selecting exosome sources, isolating and characterizing exosomes, loading them with therapeutic cargo, and evaluating their efficacy in in vitro models. The discussion of findings explores exosome isolation, cargo loading efficiency, uptake by neuronal cells, therapeutic efficacy, and comparisons with traditional delivery methods. The conclusion summarizes key findings, implications for clinical practice, recommendations for future research, and the potential of exosome-based drug delivery systems for Alzheimer’s disease treatment.

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