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Introduction

Drug-induced hepatotoxicity is a major concern in clinical practice and drug development, as it is one of the leading causes of drug withdrawal from the market and liver transplantation. Long non-coding RNAs (lncRNAs) have recently emerged as key regulators of gene expression and cellular processes, and their dysregulation has been implicated in various diseases, including cancer, cardiovascular diseases, and neurological disorders. However, the role of lncRNAs in the regulation of drug-induced hepatotoxicity remains largely unexplored.

This thesis aims to explore the role of lncRNAs in the regulation of drug-induced hepatotoxicity, with a focus on identifying potential lncRNAs involved in the pathogenesis of drug-induced liver injury and elucidating the underlying molecular mechanisms. By understanding the role of lncRNAs in drug-induced hepatotoxicity, new insights may be gained into the mechanisms of liver injury and potential therapeutic targets for the prevention and treatment of drug-induced liver injury.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objectives of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Drug-induced Hepatotoxicity
2.2 Role of lncRNAs in Gene Regulation
2.3 lncRNAs in Liver Diseases
2.4 lncRNAs in Drug Metabolism and Toxicity
2.5 Current Approaches to Studying lncRNAs
2.6 Regulatory Mechanisms of lncRNAs
2.7 Methods for lncRNA Expression Profiling
2.8 lncRNAs as Biomarkers in Liver Injury
2.9 Potential Therapeutic Targets in Drug-Induced Hepatotoxicity
2.10 Gaps in Knowledge

Chapter 3: Research Methodology
3.1 Study Design
3.2 Sample Collection and Processing
3.3 RNA Extraction and Profiling
3.4 Data Analysis
3.5 Validation of Candidate lncRNAs
3.6 Functional Studies
3.7 Animal Models of Drug-induced Hepatotoxicity
3.8 Statistical Analysis

Chapter 4: Discussion of Findings
4.1 Identification of Dysregulated lncRNAs in Drug-induced Hepatotoxicity
4.2 Molecular Mechanisms of lncRNAs in Liver Injury
4.3 Functional Roles of Candidate lncRNAs
4.4 Comparison with Existing Literature
4.5 Implications for Drug Development and Clinical Practice

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Contributions to Knowledge
5.3 Limitations and Future Directions
5.4 Practical Implications
5.5 Conclusion

Thesis Overview

Drug-induced hepatotoxicity is a significant clinical problem that poses challenges in both drug development and patient care. Long non-coding RNAs (lncRNAs) have emerged as potential regulators of gene expression and cellular processes, with dysregulation of lncRNAs implicated in various diseases, including liver injury. However, the specific role of lncRNAs in drug-induced hepatotoxicity remains unclear.

This thesis aims to explore the role of lncRNAs in the regulation of drug-induced hepatotoxicity by identifying dysregulated lncRNAs in drug-induced liver injury, elucidating the molecular mechanisms underlying lncRNA-mediated liver injury, and exploring the potential of lncRNAs as therapeutic targets and biomarkers. The study design involves RNA profiling, functional studies, and validation in animal models of drug-induced liver injury.

By investigating the role of lncRNAs in drug-induced hepatotoxicity, this research may provide new insights into the mechanisms of liver injury, identify potential therapeutic targets, and contribute to the development of strategies for the prevention and treatment of drug-induced liver injury. The findings of this study may have implications for drug development, clinical practice, and personalized medicine in the management of drug-induced hepatotoxicity.

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