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Introduction

Memory reconsolidation is a fundamental process by which memories are recalled and then saved again for future retrieval. This process is essential for updating and modifying memories based on new experiences and information, and disruptions in memory reconsolidation have been implicated in various psychiatric disorders such as post-traumatic stress disorder (PTSD) and addiction. Optogenetics is a cutting-edge technology that allows for precise control of neural activity using light, and has shown promise in the study of memory and cognition. This thesis aims to explore the use of optogenetics for the study of memory reconsolidation and updating, with the ultimate goal of gaining a better understanding of the neural mechanisms underlying these processes.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Introduction to memory reconsolidation
2.2 Neural mechanisms of memory reconsolidation
2.3 Optogenetics: principles and applications
2.4 Previous studies using optogenetics to study memory
2.5 Memory updating and its behavioral manifestations
2.6 Clinical implications of memory reconsolidation deficits
2.7 Challenges in studying memory reconsolidation
2.8 Ethical considerations in optogenetics research
2.9 Future directions in the field
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Animal models used
3.3 Optogenetic tools and techniques
3.4 Memory reconsolidation paradigms
3.5 Data analysis methods
3.6 Ethical considerations
3.7 Sample size determination
3.8 Statistical analysis plan

Chapter 4: Discussion of Findings
4.1 Effects of optogenetic manipulation on memory reconsolidation
4.2 Neural circuits involved in memory updating
4.3 Comparison of optogenetic and pharmacological approaches
4.4 Implications for psychiatric disorders
4.5 Limitations of the study
4.6 Future directions for research
4.7 Theoretical implications of the findings

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for future research
5.4 Conclusion and recommendations

Thesis Overview:

The study of memory reconsolidation and updating is a critical aspect of cognitive neuroscience, with important implications for understanding psychiatric disorders and developing novel therapies. This thesis explores the use of optogenetics, a powerful tool that allows for precise control of neural activity, in investigating the neural mechanisms underlying memory reconsolidation and updating. The literature review provides a comprehensive overview of the current understanding of memory reconsolidation, optogenetics, and memory updating, highlighting the gaps in knowledge and the potential for optogenetics to fill these gaps. The research methodology section outlines the experimental design, animal models, optogenetic tools, memory reconsolidation paradigms, and data analysis methods used in this study. The discussion of findings chapter presents the results of the experiments and discusses the implications of the findings for our understanding of memory reconsolidation and updating. Finally, the conclusion and summary chapter summarizes the key findings, contributions to the field, implications for future research, and recommendations for further studies in this area. Overall, this thesis aims to make a significant contribution to the field of cognitive neuroscience and pave the way for further research using optogenetics to study memory reconsolidation and updating.

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