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Introduction

Chaperones are a class of proteins that play a crucial role in ensuring the proper folding, stability, and function of other proteins within the cell. These proteins act as molecular guardians, preventing misfolding and aggregation of client proteins, as well as assisting in their transport and degradation. In recent years, the role of chaperones in drug response has gained significant attention, as they have been implicated in both the efficacy and toxicity of various pharmacological agents.

This thesis aims to explore the role of chaperones in drug response, with a particular focus on their involvement in modulating drug sensitivity and resistance. By elucidating the mechanisms by which chaperones influence the cellular response to drugs, we hope to gain a better understanding of how these processes can be targeted for improved therapeutic outcomes.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
– Overview of chaperones and their role in protein folding
– Chaperones as regulators of drug sensitivity and resistance
– Impact of chaperones on drug metabolism and pharmacokinetics
– Chaperones as therapeutic targets in cancer and other diseases
– Role of chaperones in neurodegenerative disorders
– Chaperones and drug-induced toxicity
– Regulatory mechanisms of chaperone expression and activity
– Chaperones in personalized medicine
– Current strategies for targeting chaperones in drug development
– Future perspectives on the role of chaperones in drug response

Chapter 3: Research Methodology
– Study design and rationale
– Selection of study subjects
– Data collection and analysis methods
– Experimental approaches and techniques
– Statistical methods
– Ethical considerations
– Quality control measures
– Limitations of the research methodology

Chapter 4: Discussion of Findings
– Analysis of the role of chaperones in drug response
– Interpretation of study results
– Comparison with existing literature
– Implications for clinical practice and drug development
– Future research directions
– Strengths and limitations of the study

Chapter 5: Conclusion and Summary
– Summary of key findings
– Conclusions drawn from the study
– Recommendations for future research
– Practical implications for the field of pharmacology
– Final thoughts on the role of chaperones in drug response

Thesis Overview:
Chaperones are crucial players in maintaining protein homeostasis within the cell, and their role in drug response has significant implications for pharmacology and personalized medicine. This thesis seeks to investigate the intricate mechanisms by which chaperones modulate drug sensitivity and resistance, with a focus on their potential as therapeutic targets in various diseases. Through a comprehensive review of the literature, the research methodology employed, and a detailed discussion of findings, this thesis aims to provide valuable insights into the role of chaperones in drug response and pave the way for future advancements in this field.

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