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Introduction:

Alzheimer’s disease is a progressive neurodegenerative disorder that primarily affects memory, cognition, and behavior. As the most common form of dementia, it poses a significant public health challenge worldwide. One of the key cognitive deficits seen in Alzheimer’s disease is the impairment of semantic memory, which refers to our knowledge of facts, concepts, and meanings about the world around us. Neuroimaging techniques provide a valuable tool for studying the neural substrates of semantic memory and how they are affected in Alzheimer’s disease.

This thesis aims to review the current literature on neuroimaging studies of semantic memory in Alzheimer’s disease, with a focus on understanding the underlying neural mechanisms and potential biomarkers. By synthesizing existing research in this field, we hope to contribute towards a better understanding of the cognitive and neural changes associated with semantic memory impairment in Alzheimer’s disease.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Alzheimer’s disease
2.2 Semantic memory and its neural basis
2.3 Neuroimaging techniques and their applications
2.4 Neuroimaging studies of semantic memory in Alzheimer’s disease
2.5 Structural and functional changes in the brain
2.6 Biomarkers of semantic memory impairment
2.7 Challenges and limitations in neuroimaging studies
2.8 Future directions in research
2.9 Summary of findings

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Data collection procedures
3.4 Neuroimaging analysis techniques
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Validation of measures
3.8 Reliability and validity
3.9 Data interpretation

Chapter 4: Discussion of Findings
4.1 Overview of key findings
4.2 Comparison with existing literature
4.3 Implications for clinical practice
4.4 Limitations of the study
4.5 Recommendations for future research
4.6 Theoretical implications
4.7 Practical implications
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for practice
5.4 Recommendations for future research
5.5 Concluding remarks

Thesis Overview:

The current thesis focuses on the neuroimaging of semantic memory in Alzheimer’s disease. It includes a comprehensive review of the literature on the topic, covering the neural basis of semantic memory, neuroimaging techniques, findings from existing studies, and future directions for research. The research methodology section outlines the design, participant selection, data collection, and analysis procedures employed in the study. The discussion of findings highlights key results, compares them with previous research, and discusses their implications for clinical practice and theoretical understanding. The conclusion summarizes the key findings, contributions to the field, recommendations for future research, and concluding remarks. Through this thesis, we aim to contribute towards a better understanding of the neural correlates of semantic memory impairment in Alzheimer’s disease and potential biomarkers for early detection and monitoring of the disease.

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